ID   PPCS1_ORYSJ             Reviewed;         321 AA.
AC   Q69S81; A0A0P0VKL9;
DT   11-JUN-2014, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Phosphopantothenate--cysteine ligase 1;
DE            EC=6.3.2.5;
DE   AltName: Full=Phosphopantothenoylcysteine synthetase 1;
DE            Short=PPC synthetase 1;
GN   OrderedLocusNames=Os02g0575200, LOC_Os02g36550;
GN   ORFNames=OsJ_07236, P0703B01.18;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Catalyzes the first step in the biosynthesis of coenzyme A
CC       from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate
CC       to form 4-phosphopantothenoylcysteine. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP +
CC         diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine;
CC         Xref=Rhea:RHEA:19397, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:35235, ChEBI:CHEBI:37563,
CC         ChEBI:CHEBI:59458, ChEBI:CHEBI:60377; EC=6.3.2.5;
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC       pantothenate: step 2/5.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PPC synthetase family. {ECO:0000305}.
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DR   EMBL; AP005116; BAD33352.1; -; Genomic_DNA.
DR   EMBL; AP008208; BAF09125.1; -; Genomic_DNA.
DR   EMBL; AP014958; BAS79374.1; -; Genomic_DNA.
DR   EMBL; CM000139; EEE57240.1; -; Genomic_DNA.
DR   EMBL; AK069567; BAG91492.1; -; mRNA.
DR   RefSeq; XP_015624140.1; XM_015768654.1.
DR   AlphaFoldDB; Q69S81; -.
DR   SMR; Q69S81; -.
DR   STRING; 4530.OS02T0575200-01; -.
DR   PaxDb; Q69S81; -.
DR   PRIDE; Q69S81; -.
DR   EnsemblPlants; Os02t0575200-01; Os02t0575200-01; Os02g0575200.
DR   GeneID; 4329749; -.
DR   Gramene; Os02t0575200-01; Os02t0575200-01; Os02g0575200.
DR   KEGG; osa:4329749; -.
DR   eggNOG; KOG2728; Eukaryota.
DR   HOGENOM; CLU_042326_0_1_1; -.
DR   InParanoid; Q69S81; -.
DR   OMA; WEVVFVT; -.
DR   OrthoDB; 1292767at2759; -.
DR   UniPathway; UPA00241; UER00353.
DR   Proteomes; UP000000763; Chromosome 2.
DR   Proteomes; UP000007752; Chromosome 2.
DR   Proteomes; UP000059680; Chromosome 2.
DR   Genevisible; Q69S81; OS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004632; F:phosphopantothenate--cysteine ligase activity; IBA:GO_Central.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.10300; -; 1.
DR   InterPro; IPR035929; CoaB-like_sf.
DR   InterPro; IPR007085; DNA/pantothenate-metab_flavo_C.
DR   Pfam; PF04127; DFP; 2.
DR   SUPFAM; SSF102645; SSF102645; 1.
PE   2: Evidence at transcript level;
KW   Coenzyme A biosynthesis; Ligase; Reference proteome.
FT   CHAIN           1..321
FT                   /note="Phosphopantothenate--cysteine ligase 1"
FT                   /id="PRO_0000429409"
SQ   SEQUENCE   321 AA;  35321 MW;  FBE6A71BEF24EA6B CRC64;
     MVAAEENPES FFAAAPPLRD ADAVAARLGE FIARNSSAAG AGGGGRRIVC VTSGGTTVPL
     EQRCVRYIDN FSSGHRGAAS TEYFLKAGYA VIFLHRRGSC QPYCRFLPDD SFLKFFDVDA
     ESKVQVAECH APVVKKAIGD YCKAIEGGYL LKLPFTTIFE YLQLLKMVAT SISSAGPLGM
     FYLAAAVSDF YVPWDSMAKH KIQSGGGPLD MRLSQVPKML SVLRNQWAPL AFCISFKLET
     DSDILIQKAD MALNKYKMNI VVANLLATYK EEVIIVTDKE RSTIRKMNKD EDLEMQIIKI
     LSQNHSKYIC GSTNGCVQSP Y