ATCL_MYCGE
ID ATCL_MYCGE Reviewed; 874 AA.
AC P47317;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Probable cation-transporting P-type ATPase;
DE EC=7.2.2.-;
GN Name=pacL; OrderedLocusNames=MG071;
OS Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS (Mycoplasmoides genitalium).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=243273;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 404-490.
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=1945886; DOI=10.1093/nar/19.21.6027;
RA Peterson S.N., Schramm N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A random sequencing approach for placing markers on the physical map of
RT Mycoplasma genitalium.";
RL Nucleic Acids Res. 19:6027-6031(1991).
CC -!- FUNCTION: Could mediate calcium influx.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type II subfamily. {ECO:0000305}.
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DR EMBL; L43967; AAC71289.1; -; Genomic_DNA.
DR EMBL; X61532; CAA43744.1; -; Genomic_DNA.
DR PIR; H64207; H64207.
DR RefSeq; WP_009885927.1; NZ_AAGX01000011.1.
DR AlphaFoldDB; P47317; -.
DR SMR; P47317; -.
DR STRING; 243273.MG_071; -.
DR EnsemblBacteria; AAC71289; AAC71289; MG_071.
DR KEGG; mge:MG_071; -.
DR eggNOG; COG0474; Bacteria.
DR HOGENOM; CLU_002360_1_1_14; -.
DR OMA; GVHRMAK; -.
DR OrthoDB; 178322at2; -.
DR BioCyc; MGEN243273:G1GJ2-83-MON; -.
DR Proteomes; UP000000807; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0015662; F:P-type ion transporter activity; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.1110.10; -; 2.
DR Gene3D; 3.40.50.1000; -; 2.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
DR SUPFAM; SSF81653; SSF81653; 1.
DR SUPFAM; SSF81665; SSF81665; 1.
DR TIGRFAMs; TIGR01494; ATPase_P-type; 4.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Magnesium; Membrane; Metal-binding;
KW Nucleotide-binding; Phosphoprotein; Reference proteome; Translocase;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..874
FT /note="Probable cation-transporting P-type ATPase"
FT /id="PRO_0000046162"
FT TOPO_DOM 1..41
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..79
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..644
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 645..664
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 665..687
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 688..708
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 709..726
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 727..749
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 750..770
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 771..790
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 791..803
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 804..826
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 827..844
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 845..865
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 866..874
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT ACT_SITE 331
FT /note="4-aspartylphosphate intermediate"
FT /evidence="ECO:0000250"
FT BINDING 589
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 593
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
SQ SEQUENCE 874 AA; 96318 MW; EEFAADA0BD4DBF7D CRC64;
MNSWTGLSEQ AAIKSRQEHG ANFLPEKKAT PFWLLFLQQF KSLVVILLLL ASLLSFVVAI
VSGLRSNWNF NHDLIIEWVQ PFIILLTVFA NSLIGSIQEF KAQKSASALK SLTKSFTRVF
RNGELISINV SEVVVGDIIF VDAGDIIPAD GKLLQVNNLR CLESFLTGES TPVDKTIDSN
EKATILEQTN LVFSGAQVVY GSGVFQVEAV GIKTQVGKIA KTVDDSVTKL SPLQQKLEKI
GKWFSWFGLG LFAVVFLVQT ALLGFDNFTN NWSIALIGAI ALVVAIIPEG LVTFINVIFA
LSVQKLTKQK AIIKYLSVIE TLGSVQIICT DKTGTLTQNQ MKVVDHFCFN STTQTDLARA
LCLCNNASIS KDANKTGDPT EIALLEWKDR SQLDLKTYYR VYEKAFDSIR KLMTVVVQKD
NRFIVIVKGA PDVLLPLCNN VQNEVKNIEN LLDQSAGQGL RTLAVALKVL YKFDQNDQKQ
IDELENNLEF LGFVSLQDPP RKESKEAILA CKKANITPIM ITGDHLKTAT VIAKELGILT
LDNQAVLGSE LDEKKILDYR VFARVTPQQK LAIVSAWKEA GFTVSVTGDG VNDAPALIKS
DVGCCMGITG VDIAKDASDL IISDDNFATI VNGIEEGRKT FLTCKRVLLN LFLTSIAGTV
VVLLGLFILG QVFKTNLLQQ GHDFQVFSPT QLLIINLFVH GFPAVALAVQ PVKEKLMVGS
FSTKNLFYNR QGFDLIWQSL FLSFLTLLFY SLGIIYAINN RDLQTSGDLI NRAGSTCGFF
ILGASAALNS LNLMVDKPLL MTNPWFFKLV WIGSLASILV FLLIIFINPL GLVFNVLQDL
TNHPVLISYS FGGVILYMGM NEVVKLIRLG YGNI
