ID   PPDD_ECOLI              Reviewed;         146 AA.
AC   P36647; Q8KMZ6;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 2.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Prepilin peptidase-dependent protein D;
DE   Flags: Precursor;
GN   Name=ppdD; OrderedLocusNames=b0108, JW0104;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RA   Bhatia R.S.;
RL   Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=7959070; DOI=10.1016/0378-1119(94)90851-6;
RA   Whitchurch C.B., Mattick J.S.;
RT   "Escherichia coli contains a set of genes homologous to those involved in
RT   protein secretion, DNA uptake and the assembly of type-4 fimbriae in other
RT   bacteria.";
RL   Gene 150:9-15(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=8202364; DOI=10.1093/nar/22.9.1637;
RA   Fujita N., Mori H., Yura T., Ishihama A.;
RT   "Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-
RT   4.1 min (110,917-193,643 bp) region.";
RL   Nucleic Acids Res. 22:1637-1639(1994).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION TO
RP   1-5.
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [6]
RP   FUNCTION, AND PROTEOLYTIC CLEAVAGE.
RC   STRAIN=K12;
RX   PubMed=10633126; DOI=10.1128/jb.182.3.848-854.2000;
RA   Sauvonnet N., Gounon P., Pugsley A.P.;
RT   "PpdD type IV pilin of Escherichia coli K-12 can Be assembled into pili in
RT   Pseudomonas aeruginosa.";
RL   J. Bacteriol. 182:848-854(2000).
CC   -!- FUNCTION: Major component of the type IV pilus (T4P) that plays a role
CC       in cell adhesion and motility. Not produced when grown under standard
CC       laboratory conditions. {ECO:0000269|PubMed:10633126}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium. Membrane {ECO:0000255}; Single-pass
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the N-Me-Phe pilin family. {ECO:0000305}.
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DR   EMBL; L20834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; L28105; AAC36923.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC73219.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAB96678.2; -; Genomic_DNA.
DR   PIR; D64733; D64733.
DR   RefSeq; NP_414650.1; NC_000913.3.
DR   RefSeq; WP_000360904.1; NZ_SSZK01000004.1.
DR   AlphaFoldDB; P36647; -.
DR   BMRB; P36647; -.
DR   SMR; P36647; -.
DR   BioGRID; 4259343; 5.
DR   STRING; 511145.b0108; -.
DR   PaxDb; P36647; -.
DR   EnsemblBacteria; AAC73219; AAC73219; b0108.
DR   EnsemblBacteria; BAB96678; BAB96678; BAB96678.
DR   GeneID; 945817; -.
DR   KEGG; ecj:JW0104; -.
DR   KEGG; eco:b0108; -.
DR   PATRIC; fig|1411691.4.peg.2174; -.
DR   EchoBASE; EB2031; -.
DR   eggNOG; COG4969; Bacteria.
DR   HOGENOM; CLU_091705_4_1_6; -.
DR   InParanoid; P36647; -.
DR   OMA; RILTWDC; -.
DR   PhylomeDB; P36647; -.
DR   BioCyc; EcoCyc:EG12107-MON; -.
DR   PRO; PR:P36647; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0044096; C:type IV pilus; IBA:GO_Central.
DR   GO; GO:0043683; P:type IV pilus assembly; IBA:GO_Central.
DR   GO; GO:0043107; P:type IV pilus-dependent motility; IBA:GO_Central.
DR   InterPro; IPR012902; N_methyl_site.
DR   InterPro; IPR045584; Pilin-like.
DR   Pfam; PF07963; N_methyl; 1.
DR   SUPFAM; SSF54523; SSF54523; 1.
DR   TIGRFAMs; TIGR02532; IV_pilin_GFxxxE; 1.
DR   PROSITE; PS00409; PROKAR_NTER_METHYL; 1.
PE   1: Evidence at protein level;
KW   Fimbrium; Membrane; Methylation; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   PROPEP          1..6
FT                   /note="Leader sequence"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01070,
FT                   ECO:0000269|PubMed:10633126"
FT                   /id="PRO_0000024280"
FT   CHAIN           7..146
FT                   /note="Prepilin peptidase-dependent protein D"
FT                   /id="PRO_0000024281"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         7
FT                   /note="N-methylphenylalanine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01070"
FT   CONFLICT        1..5
FT                   /note="MDKQR -> DGQAT (in Ref. 3)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   146 AA;  15622 MW;  7905D78A1E8B17A0 CRC64;
     MDKQRGFTLI ELMVVIGIIA ILSAIGIPAY QNYLRKAALT DMLQTFVPYR TAVELCALEH
     GGLDTCDGGS NGIPSPTTTR YVSAMSVAKG VVSLTGQESL NGLSVVMTPG WDNANGVTGW
     TRNCNIQSDS ALQQACEDVF RFDDAN