PPDPF_HUMAN
ID PPDPF_HUMAN Reviewed; 114 AA.
AC Q9H3Y8; E1P5J2; Q4VXP1; Q9H3Y7;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Pancreatic progenitor cell differentiation and proliferation factor;
DE AltName: Full=Exocrine differentiation and proliferation factor;
GN Name=PPDPF; Synonyms=C20orf149, EXPDF;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING
RP (ISOFORM 2).
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Probable regulator of exocrine pancreas development.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H3Y8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H3Y8-2; Sequence=VSP_003823, VSP_003824;
CC -!- SIMILARITY: Belongs to the PPDPF family. {ECO:0000305}.
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DR EMBL; AL121829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW75264.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW75265.1; -; Genomic_DNA.
DR EMBL; BC002531; AAH02531.1; -; mRNA.
DR EMBL; BC056416; AAH56416.1; -; mRNA.
DR CCDS; CCDS13523.1; -. [Q9H3Y8-1]
DR RefSeq; NP_077275.1; NM_024299.2. [Q9H3Y8-1]
DR AlphaFoldDB; Q9H3Y8; -.
DR BioGRID; 122563; 2.
DR STRING; 9606.ENSP00000359198; -.
DR GlyGen; Q9H3Y8; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9H3Y8; -.
DR PhosphoSitePlus; Q9H3Y8; -.
DR BioMuta; PPDPF; -.
DR DMDM; 27734256; -.
DR EPD; Q9H3Y8; -.
DR jPOST; Q9H3Y8; -.
DR MassIVE; Q9H3Y8; -.
DR MaxQB; Q9H3Y8; -.
DR PaxDb; Q9H3Y8; -.
DR PeptideAtlas; Q9H3Y8; -.
DR PRIDE; Q9H3Y8; -.
DR ProteomicsDB; 80769; -. [Q9H3Y8-1]
DR ProteomicsDB; 80770; -. [Q9H3Y8-2]
DR Antibodypedia; 44524; 20 antibodies from 12 providers.
DR DNASU; 79144; -.
DR Ensembl; ENST00000370179.8; ENSP00000359198.3; ENSG00000125534.10. [Q9H3Y8-1]
DR GeneID; 79144; -.
DR KEGG; hsa:79144; -.
DR MANE-Select; ENST00000370179.8; ENSP00000359198.3; NM_024299.4; NP_077275.1.
DR UCSC; uc002yff.4; human. [Q9H3Y8-1]
DR CTD; 79144; -.
DR DisGeNET; 79144; -.
DR GeneCards; PPDPF; -.
DR HGNC; HGNC:16142; PPDPF.
DR HPA; ENSG00000125534; Low tissue specificity.
DR neXtProt; NX_Q9H3Y8; -.
DR OpenTargets; ENSG00000125534; -.
DR PharmGKB; PA25691; -.
DR VEuPathDB; HostDB:ENSG00000125534; -.
DR eggNOG; ENOG502S1KD; Eukaryota.
DR GeneTree; ENSGT00390000009113; -.
DR HOGENOM; CLU_157362_0_0_1; -.
DR InParanoid; Q9H3Y8; -.
DR OrthoDB; 1540584at2759; -.
DR PhylomeDB; Q9H3Y8; -.
DR TreeFam; TF333000; -.
DR PathwayCommons; Q9H3Y8; -.
DR BioGRID-ORCS; 79144; 22 hits in 1076 CRISPR screens.
DR ChiTaRS; PPDPF; human.
DR GenomeRNAi; 79144; -.
DR Pharos; Q9H3Y8; Tdark.
DR PRO; PR:Q9H3Y8; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9H3Y8; protein.
DR Bgee; ENSG00000125534; Expressed in lower esophagus mucosa and 178 other tissues.
DR ExpressionAtlas; Q9H3Y8; baseline and differential.
DR Genevisible; Q9H3Y8; HS.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR InterPro; IPR026754; PPDPF.
DR PANTHER; PTHR14572; PTHR14572; 1.
DR Pfam; PF15060; PPDFL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; Differentiation;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..114
FT /note="Pancreatic progenitor cell differentiation and
FT proliferation factor"
FT /id="PRO_0000079468"
FT REGION 22..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 67..70
FT /note="FMAT -> PPTL (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_003823"
FT VAR_SEQ 71..114
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_003824"
SQ SEQUENCE 114 AA; 11777 MW; CCFE0A5207C887FE CRC64;
MAAIPSSGSL VATHDYYRRR LGSTSSNSSC SSTECPGEAI PHPPGLPKAD PGHWWASFFF
GKSTLPFMAT VLESAEHSEP PQASSSMTAC GLARDAPRKQ PGGQSSTASA GPPS
