PPDPF_MOUSE
ID PPDPF_MOUSE Reviewed; 115 AA.
AC Q9CR37; Q58EU5;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Pancreatic progenitor cell differentiation and proliferation factor;
DE AltName: Full=Exocrine differentiation and proliferation factor;
GN Name=Ppdpf; Synonyms=Exdpf;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Probable regulator of exocrine pancreas development.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PPDPF family. {ECO:0000305}.
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DR EMBL; AK003282; BAB22687.1; -; mRNA.
DR EMBL; AK012037; BAB27988.1; -; mRNA.
DR EMBL; AK012327; BAB28164.1; -; mRNA.
DR EMBL; AK154758; BAE32808.1; -; mRNA.
DR EMBL; AL450341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466626; EDL07387.1; -; Genomic_DNA.
DR EMBL; CH466626; EDL07392.1; -; Genomic_DNA.
DR EMBL; CH466626; EDL07393.1; -; Genomic_DNA.
DR EMBL; BC091753; AAH91753.1; -; mRNA.
DR EMBL; BC100439; AAI00440.1; -; mRNA.
DR EMBL; BC058516; AAH58516.1; -; mRNA.
DR CCDS; CCDS17202.1; -.
DR RefSeq; NP_079874.1; NM_025598.2.
DR RefSeq; XP_006500766.1; XM_006500703.2.
DR AlphaFoldDB; Q9CR37; -.
DR STRING; 10090.ENSMUSP00000016488; -.
DR PhosphoSitePlus; Q9CR37; -.
DR MaxQB; Q9CR37; -.
DR PaxDb; Q9CR37; -.
DR PeptideAtlas; Q9CR37; -.
DR PRIDE; Q9CR37; -.
DR ProteomicsDB; 291712; -.
DR Antibodypedia; 44524; 20 antibodies from 12 providers.
DR Ensembl; ENSMUST00000016488; ENSMUSP00000016488; ENSMUSG00000016344.
DR Ensembl; ENSMUST00000108841; ENSMUSP00000104469; ENSMUSG00000016344.
DR GeneID; 66496; -.
DR KEGG; mmu:66496; -.
DR UCSC; uc008oli.1; mouse.
DR CTD; 79144; -.
DR MGI; MGI:1913746; Ppdpf.
DR VEuPathDB; HostDB:ENSMUSG00000016344; -.
DR eggNOG; ENOG502S1KD; Eukaryota.
DR GeneTree; ENSGT00390000009113; -.
DR HOGENOM; CLU_157362_0_0_1; -.
DR InParanoid; Q9CR37; -.
DR OMA; GSAECPG; -.
DR OrthoDB; 1540584at2759; -.
DR PhylomeDB; Q9CR37; -.
DR TreeFam; TF333000; -.
DR BioGRID-ORCS; 66496; 4 hits in 70 CRISPR screens.
DR ChiTaRS; Ppdpf; mouse.
DR PRO; PR:Q9CR37; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9CR37; protein.
DR Bgee; ENSMUSG00000016344; Expressed in ganglionic eminence and 68 other tissues.
DR Genevisible; Q9CR37; MM.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR InterPro; IPR026754; PPDPF.
DR PANTHER; PTHR14572; PTHR14572; 1.
DR Pfam; PF15060; PPDFL; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Phosphoprotein; Reference proteome.
FT CHAIN 1..115
FT /note="Pancreatic progenitor cell differentiation and
FT proliferation factor"
FT /id="PRO_0000079469"
FT REGION 21..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 73..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H3Y8"
SQ SEQUENCE 115 AA; 12260 MW; 27DD4A1F949D95C0 CRC64;
MAAIPSSGSL VATHDYYRRR LGSSSSSSSG GSAEYPGDAV LQSPGLPKAD PGHWWASFFF
GKSTLPFMTT VLESPERSAE SPQVSRSPMT CGLTPETMKQ QPVIHSGQTN PRDLS
