ID   PPE01_MYCTU             Reviewed;         463 AA.
AC   P9WI49; L0T5N5; Q10892;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 30.
DE   RecName: Full=Uncharacterized PPE family protein PPE1;
GN   Name=PPE1; OrderedLocusNames=Rv0096; ORFNames=MTCY251.15;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP42821.1; -; Genomic_DNA.
DR   PIR; H70750; H70750.
DR   RefSeq; WP_003400781.1; NZ_NVQJ01000053.1.
DR   RefSeq; YP_177690.1; NC_000962.3.
DR   AlphaFoldDB; P9WI49; -.
DR   SMR; P9WI49; -.
DR   STRING; 83332.Rv0096; -.
DR   PaxDb; P9WI49; -.
DR   DNASU; 886938; -.
DR   GeneID; 886938; -.
DR   KEGG; mtu:Rv0096; -.
DR   TubercuList; Rv0096; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; DLLWYPY; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR043641; PPE-PPW_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
DR   Pfam; PF18878; PPE-PPW; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..463
FT                   /note="Uncharacterized PPE family protein PPE1"
FT                   /id="PRO_0000217842"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        419..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          303..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   463 AA;  46895 MW;  42D9D66A033D0DD8 CRC64;
     MAIPPEVHSG LLSAGCGPGS LLVAAQQWQE LSDQYALACA ELGQLLGEVQ ASSWQGTAAT
     QYVAAHGPYL AWLEQTAINS AVTAAQHVAA AAAYCSALAA MPTPAELAAN HAIHGVLIAT
     NFFGINTVPI ALNEADYVRM WLQAADTMAA YQAVADAATV AVPSTQPAPP IRAPGGDAAD
     TRLDVLSSIG QLIRDILDFI ANPYKYFLEF FEQFGFSPAV TVVLALVALQ LYDFLWYPYY
     ASYGLLLLPF FTPTLSALTA LSALIHLLNL PPAGLLPIAA ALGPGDQWGA NLAVAVTPAT
     AAVPGGSPPT SNPAPAAPSS NSVGSASAAP GISYAVPGLA PPGVSSGPKA GTKSPDTAAD
     TLATAGAARP GLARAHRRKR SESGVGIRGY RDEFLDATAT VDAATDVPAP ANAAGSQGAG
     TLGFAGTAPT TSGAAAGMVQ LSSHSTSTTV PLLPTTWTTD AEQ