ID   PPE03_MYCTU             Reviewed;         536 AA.
AC   P9WI45; L0T315; Q79FY8; Q8VKN6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Uncharacterized PPE family protein PPE3;
GN   Name=PPE3; OrderedLocusNames=Rv0280;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43010.1; -; Genomic_DNA.
DR   PIR; F70835; F70835.
DR   RefSeq; WP_010886073.1; NZ_NVQJ01000026.1.
DR   RefSeq; YP_177709.1; NC_000962.3.
DR   AlphaFoldDB; P9WI45; -.
DR   SMR; P9WI45; -.
DR   STRING; 83332.Rv0280; -.
DR   PaxDb; P9WI45; -.
DR   GeneID; 886619; -.
DR   KEGG; mtu:Rv0280; -.
DR   TubercuList; Rv0280; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; DWPTHIL; -.
DR   PhylomeDB; P9WI45; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR043641; PPE-PPW_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
DR   Pfam; PF18878; PPE-PPW; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..536
FT                   /note="Uncharacterized PPE family protein PPE3"
FT                   /id="PRO_0000378474"
FT   REGION          501..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   536 AA;  54707 MW;  20D78E7974124598 CRC64;
     MTLWMASPPE VHSALLSSGP GPGSVLSAAG VWSSLSAEYA AVADELIGLL GAVQTGAWQG
     PSAAAYVAAH APYLAWLMRA SETSAEAAAR HETVAAAYTT AVAAMPTLVE LAANHTLHGV
     LVATNFFGIN TIPIALNEAD YARMWTQAAS TMATYQAVAE AAVASAPQTT PAPPILAAEA
     ADDDHDHDHD HGGEPTPLDY LVAEILRIIS GGRLIWDPAE GTMNGIPFED YTDAAQPIWW
     VVRAIEFSKD FETFVQELFV NPVEAFQFYF ELLLFDYPTH IVQIVEALSQ SPQLLAVALG
     SVISNLGAVT GFAGLSGLAG MQPAAIPALA PVAAAPSTLP AVAMAPTMAA PGAAVASAAA
     PASAPAASTV ASATPAPPPA PGAAGFGYPY AIAPPGIGFG SGMSASASAQ RKAPQPDSAA
     AAAAAAAVRD QARARRRRRV TRRGYGDEFM DMNIDVDPDW GPPPGEDPVT STVASDRGAG
     HLGFAGTARR EAVADAAGMT TLAGDDFGDG PTTPMVPGSW DPDRDAPGSA EPGDRG