ID   PPE10_MYCMM             Reviewed;         488 AA.
AC   B2HQQ1;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=PPE family protein PPE10 {ECO:0000305};
GN   Name=PPE10 {ECO:0000303|PubMed:27280885};
GN   OrderedLocusNames=MMAR_0761 {ECO:0000312|EMBL:ACC39221.1};
OS   Mycobacterium marinum (strain ATCC BAA-535 / M).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=216594;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-535 / M;
RX   PubMed=18403782; DOI=10.1101/gr.075069.107;
RA   Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA   Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA   Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA   Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA   Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA   Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT   "Insights from the complete genome sequence of Mycobacterium marinum on the
RT   evolution of Mycobacterium tuberculosis.";
RL   Genome Res. 18:729-741(2008).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=E11;
RX   PubMed=27280885; DOI=10.1371/journal.ppat.1005696;
RA   Ates L.S., van der Woude A.D., Bestebroer J., van Stempvoort G.,
RA   Musters R.J., Garcia-Vallejo J.J., Picavet D.I., van de Weerd R.,
RA   Maletta M., Kuijl C.P., van der Wel N.N., Bitter W.;
RT   "The ESX-5 system of pathogenic mycobacteria is involved in capsule
RT   integrity and virulence through its substrate PPE10.";
RL   PLoS Pathog. 12:e1005696-e1005696(2016).
CC   -!- FUNCTION: Plays a major role in the integrity and stability of the
CC       capsule. {ECO:0000269|PubMed:27280885}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27280885}.
CC       Note=Secreted via the ESX-5 / type VII secretion system (T7SS).
CC       {ECO:0000269|PubMed:27280885}.
CC   -!- DISRUPTION PHENOTYPE: Mutants have impaired capsule integrity as well
CC       as reduced surface hydrophobicity. Mutants have reduced amounts of
CC       surface localized proteins and glycolipids, and morphological
CC       differences in the capsular layer. Disruption of the gene is associated
CC       with reduced ubiquitin association in cell infection and attenuated
CC       virulence in the early stages of infection.
CC       {ECO:0000269|PubMed:27280885}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; CP000854; ACC39221.1; -; Genomic_DNA.
DR   RefSeq; WP_012392709.1; NC_010612.1.
DR   AlphaFoldDB; B2HQQ1; -.
DR   SMR; B2HQQ1; -.
DR   STRING; 216594.MMAR_0761; -.
DR   EnsemblBacteria; ACC39221; ACC39221; MMAR_0761.
DR   GeneID; 64259502; -.
DR   KEGG; mmi:MMAR_0761; -.
DR   eggNOG; COG5651; Bacteria.
DR   HOGENOM; CLU_000243_4_6_11; -.
DR   OMA; ATQYMAW; -.
DR   OrthoDB; 1939251at2; -.
DR   PHI-base; PHI:6278; -.
DR   Proteomes; UP000001190; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR002989; Mycobac_pentapep.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF01469; Pentapeptide_2; 4.
DR   Pfam; PF00823; PPE; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted.
FT   CHAIN           1..488
FT                   /note="PPE family protein PPE10"
FT                   /id="PRO_0000450444"
FT   REGION          207..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          443..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  47142 MW;  43A7C225C0513051 CRC64;
     MTNPHFAWLP PEINSALMFA GPGAGPLLAA AAAWGGLAEE LASAVSSFSS VTSELTSGSW
     LGPSAAAMMA VATQYMAWLG AAAAQAEQAA AQAAVTAGAF ESALAATVQP AVVTANRGLM
     QVLAATNWLG FNTPAIMDIE AAYEQMWALD VAAMAAYHAE ASAAASALAP WKQVLRNLGI
     DIGKNGQINL GFGNSGTGNV GNNNVGNNNW GSGNTGSSNV GTGNTGSSNI GSGNTGNSNV
     GLGNLGSGNV GFGNTGNGDF GFGLTGDHQF GFGGFNSGSG NVGIGNSGTG NVGFFNSGNG
     NMGIGNSGSL NSGLGNSGSM STGFGTASMS SGMWQSMHGS DMASSTSLAS SATYATGGTA
     TLSSGILSSA LAHTGGLNPA LAGGLTPTAA TPAAAAPAAA APVAAAAADA GPVSAGANSG
     STAGAGLRSP AAGYSGLYNS ANSDAGARSV ATREAPANAG AGIPRSSFYP NRETADSEAD
     IQLPLRTE