ID   PPE10_MYCTO             Reviewed;         487 AA.
AC   P9WI40; L0T6H1; O53727; P42611;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=PPE family protein PPE10 {ECO:0000305};
GN   Name=PPE10; OrderedLocusNames=MT0458;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Plays a major role in the integrity and stability of the
CC       capsule. {ECO:0000250|UniProtKB:B2HQQ1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WI41}.
CC       Note=Secreted via the ESX-5 / type VII secretion system (T7SS).
CC       {ECO:0000250|UniProtKB:P9WI41}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK44681.1; -; Genomic_DNA.
DR   PIR; C70830; C70830.
DR   RefSeq; WP_003402239.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WI40; -.
DR   SMR; P9WI40; -.
DR   EnsemblBacteria; AAK44681; AAK44681; MT0458.
DR   KEGG; mtc:MT0458; -.
DR   PATRIC; fig|83331.31.peg.485; -.
DR   HOGENOM; CLU_000243_4_6_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR002989; Mycobac_pentapep.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF01469; Pentapeptide_2; 2.
DR   Pfam; PF00823; PPE; 1.
PE   3: Inferred from homology;
KW   Secreted.
FT   CHAIN           1..487
FT                   /note="PPE family protein PPE10"
FT                   /id="PRO_0000428073"
FT   REGION          398..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        424..462
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   487 AA;  47247 MW;  97234D5B316C8C7F CRC64;
     MTSPHFAWLP PEINSALMFA GPGSGPLIAA ATAWGELAEE LLASIASLGS VTSELTSGAW
     LGPSAAAMMA VATQYLAWLS TAAAQAEQAA AQAMAIATAF EAALAATVQP AVVAANRGLM
     QLLAATNWFG QNAPALMDVE AAYEQMWALD VAAMAGYHFD ASAAVAQLAP WQQVLRNLGI
     DIGKNGQINL GFGNTGSGNI GNNNIGNNNI GSGNTGTGNI GSGNTGSGNL GLGNLGDGNI
     GFGNTGSGNI GFGITGDHQM GFGGFNSGSG NIGFGNSGTG NVGLFNSGSG NIGIGNSGSL
     NSGIGTSGTI NAGLGSAGSL NTSFWNAGMQ NAALGSAAGS EAALVSSAGY ATGGMSTAAL
     SSGILASALG STGGLQHGLA NVLNSGLTNT PVAAPASAPV GGLDSGNPNP GSGSAAAGSG
     ANPGLRSPGT SYPSFVNSGS NDSGLRNTAV REPSTPGSGI PKSNFYPSPD RESAYASPRI
     GQPVGSE