ID   PPE10_MYCTU             Reviewed;         487 AA.
AC   P9WI41; L0T6H1; O53727; P42611;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=PPE family protein PPE10 {ECO:0000305};
GN   Name=PPE10; OrderedLocusNames=Rv0442c; ORFNames=MTV037.06c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=3029018; DOI=10.1128/jb.169.3.1080-1088.1987;
RA   Shinnick T.M.;
RT   "The 65-kilodalton antigen of Mycobacterium tuberculosis.";
RL   J. Bacteriol. 169:1080-1088(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=19602152; DOI=10.1111/j.1365-2958.2009.06783.x;
RA   Abdallah A.M., Verboom T., Weerdenburg E.M., Gey van Pittius N.C.,
RA   Mahasha P.W., Jimenez C., Parra M., Cadieux N., Brennan M.J.,
RA   Appelmelk B.J., Bitter W.;
RT   "PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the
RT   type VII secretion system ESX-5.";
RL   Mol. Microbiol. 73:329-340(2009).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Plays a major role in the integrity and stability of the
CC       capsule. {ECO:0000250|UniProtKB:B2HQQ1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19602152}.
CC       Note=Secreted via the ESX-5 / type VII secretion system (T7SS).
CC       {ECO:0000269|PubMed:19602152}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA88235.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M15467; AAA88235.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL123456; CCP43173.1; -; Genomic_DNA.
DR   PIR; C70830; C70830.
DR   RefSeq; WP_003402239.1; NZ_NVQJ01000002.1.
DR   RefSeq; YP_177726.2; NC_000962.3.
DR   AlphaFoldDB; P9WI41; -.
DR   SMR; P9WI41; -.
DR   STRING; 83332.Rv0442c; -.
DR   PaxDb; P9WI41; -.
DR   DNASU; 886340; -.
DR   GeneID; 886340; -.
DR   KEGG; mtu:Rv0442c; -.
DR   TubercuList; Rv0442c; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; ATQYMAW; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042783; P:evasion of host immune response; IMP:MTBBASE.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR002989; Mycobac_pentapep.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF01469; Pentapeptide_2; 2.
DR   Pfam; PF00823; PPE; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted.
FT   CHAIN           1..487
FT                   /note="PPE family protein PPE10"
FT                   /id="PRO_0000217843"
FT   REGION          398..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        424..462
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        96
FT                   /note="I -> T (in Ref. 1; AAA88235)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        211
FT                   /note="G -> GNNNIG (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   487 AA;  47247 MW;  97234D5B316C8C7F CRC64;
     MTSPHFAWLP PEINSALMFA GPGSGPLIAA ATAWGELAEE LLASIASLGS VTSELTSGAW
     LGPSAAAMMA VATQYLAWLS TAAAQAEQAA AQAMAIATAF EAALAATVQP AVVAANRGLM
     QLLAATNWFG QNAPALMDVE AAYEQMWALD VAAMAGYHFD ASAAVAQLAP WQQVLRNLGI
     DIGKNGQINL GFGNTGSGNI GNNNIGNNNI GSGNTGTGNI GSGNTGSGNL GLGNLGDGNI
     GFGNTGSGNI GFGITGDHQM GFGGFNSGSG NIGFGNSGTG NVGLFNSGSG NIGIGNSGSL
     NSGIGTSGTI NAGLGSAGSL NTSFWNAGMQ NAALGSAAGS EAALVSSAGY ATGGMSTAAL
     SSGILASALG STGGLQHGLA NVLNSGLTNT PVAAPASAPV GGLDSGNPNP GSGSAAAGSG
     ANPGLRSPGT SYPSFVNSGS NDSGLRNTAV REPSTPGSGI PKSNFYPSPD RESAYASPRI
     GQPVGSE