ID   PPE11_MYCTU             Reviewed;         518 AA.
AC   P9WI39; L0T5E9; Q6MX41; Q7D9S7;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=PPE family protein PPE11 {ECO:0000305};
GN   Name=PPE11 {ECO:0000303|PubMed:30366125}; OrderedLocusNames=Rv0453;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   FUNCTION, EXPRESSION IN M.SMEGMATIS, AND SUBCELLULAR LOCATION.
RX   PubMed=30366125; DOI=10.1016/j.micpath.2018.10.031;
RA   Peng X., Luo T., Zhai X., Zhang C., Suo J., Ma P., Wang C., Bao L.;
RT   "PPE11 of Mycobacterium tuberculosis can alter host inflammatory response
RT   and trigger cell death.";
RL   Microb. Pathog. 126:45-55(2019).
CC   -!- FUNCTION: May play an important role in the persistence of mycobacteria
CC       in host cells. May regulate the innate immune response of macrophages
CC       by promoting the production of pro-inflammatory cytokines and
CC       inhibiting the production of anti-inflammatory cytokines. Promotes the
CC       death of macrophages during infection. {ECO:0000269|PubMed:30366125}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC       {ECO:0000269|PubMed:30366125}. Note=Cell wall-associated.
CC       {ECO:0000269|PubMed:30366125}.
CC   -!- MISCELLANEOUS: Expression in M.smegmatis enhances the ability to resist
CC       in vitro stress and early survival in macrophages. Macrophages infected
CC       with recombinant M.smegmatis produce significantly greater amounts of
CC       interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha and an
CC       early decrease in IL-10 along with higher levels of host cell death.
CC       {ECO:0000269|PubMed:30366125}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43184.1; -; Genomic_DNA.
DR   PIR; F70831; F70831.
DR   RefSeq; WP_003402284.1; NZ_NVQJ01000002.1.
DR   RefSeq; YP_177727.1; NC_000962.3.
DR   AlphaFoldDB; P9WI39; -.
DR   SMR; P9WI39; -.
DR   STRING; 83332.Rv0453; -.
DR   PaxDb; P9WI39; -.
DR   DNASU; 886317; -.
DR   GeneID; 886317; -.
DR   KEGG; mtu:Rv0453; -.
DR   TubercuList; Rv0453; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; ASAGAWN; -.
DR   PhylomeDB; P9WI39; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR043641; PPE-PPW_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
DR   Pfam; PF18878; PPE-PPW; 1.
PE   3: Inferred from homology;
KW   Cell wall; Reference proteome; Secreted; Virulence.
FT   CHAIN           1..518
FT                   /note="PPE family protein PPE11"
FT                   /id="PRO_0000379585"
FT   REGION          177..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          346..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          435..458
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   518 AA;  52837 MW;  6AFB51311C2DF472 CRC64;
     MTSALIWMAS PPEVHSALLS SGPGPGPVLA AATGWSSLGR EYAAVAEELG ALLAAVQAGV
     WQGPSAESFA AACLPYLSWL TQASADCAAA AARLEAVTAA YAAALVAMPT LAELAANHAT
     HGAMVATNFF GINTIPIAVN EADYVRMWLQ AATTMATYQA VADSAVRSIP DSVPPPRILK
     SNAQSQHSSS NNSGGADPVD DFIAEILKII TGGRVIWDPE AGTVNGLPYD AYTNPGTLMW
     WIARSLELLQ DFQEFAKLLF TNPVKAFQFL VDLILFDWPT HMLQLATWLA ENPQLLVAAL
     TPAISGLGAV SGLAGLTGLV PQPPVVPAPA PDAVVPTVLP LAGTATPTTA PASAPAAGAA
     PGPPAGTATA TSASVPTSAG GFPPYLVGSG PGIDFDAGTP AGSRRAQPAA DNVTAVAAAQ
     VSARHQARRR RRAAAKERGN ADEFVDMDSG PAIPPSGERD AWASNSGVGG LGFAGTASNE
     TVAAPAGLTT LADDEFQCGP RMPMLPGAWD LGTWDRGD