ID   PPE12_MYCTU             Reviewed;         645 AA.
AC   P9WI37; L0T4T0; Q79FW4; Q7D9B9;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Uncharacterized PPE family protein PPE12;
GN   Name=PPE12; OrderedLocusNames=Rv0755c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43501.1; -; Genomic_DNA.
DR   PIR; F70825; F70825.
DR   RefSeq; WP_003898574.1; NZ_NVQJ01000035.1.
DR   RefSeq; YP_177753.1; NC_000962.3.
DR   AlphaFoldDB; P9WI37; -.
DR   STRING; 83332.Rv0755c; -.
DR   PaxDb; P9WI37; -.
DR   DNASU; 888708; -.
DR   GeneID; 888708; -.
DR   KEGG; mtu:Rv0755c; -.
DR   TubercuList; Rv0755c; -.
DR   eggNOG; COG5263; Bacteria.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; GESTHAT; -.
DR   PhylomeDB; P9WI37; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR002989; Mycobac_pentapep.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF01469; Pentapeptide_2; 5.
DR   Pfam; PF00823; PPE; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..645
FT                   /note="Uncharacterized PPE family protein PPE12"
FT                   /id="PRO_0000378476"
SQ   SEQUENCE   645 AA;  62693 MW;  348FF4265DFE15FD CRC64;
     MVGFAWLPPE TNSLRMYLGA GSRPLLAAAG AWDGLAEELH AAASSFGSVT SELAGGAWQG
     PASAAMANAA GPYASWLTAA GAQAELAARQ ARAAAGAFEE ALAGVVHPAV VQANRVRTWL
     LAVSNVFGQN APAIAAMEST YEQMWAQDVA VMAGYHAASS AAAAQLASWQ PALPNINLGV
     GNIGNLNVGN GNTGDYNLGN GNLGNANFGG GNGSAFHGQI SSFNVGSGNI GNFNLGSGNG
     NVGIGPSSFN VGSGNIGNAN VGGGNSGDNN FGFGNFGNAN IGIGNAGPNM SSPAVPTPGN
     GNVGIGNGGN GNFGGGNTGN ANIGLGNVGD GNVGFGNSGS YNFGFGNTGN NNIGIGLTGS
     NQIGFGGLNS GSGNIGFGNS GTGNIGFFNS GSGNFGVGNS GVTNTGVANS GNINTGFGNS
     GFINTGFGNA LSVNTGFGNS GQANTGIGNA GDFNTGNFNG GIINTGSFNS GAFNSGSFNG
     GDANSGFLNS GLTNTGFANS GNINTGGFNA GNLNTGFGNT TDGLGENSGF GNAGSGNSGF
     NNSGRGNSGA QNVGNLQISG FANSGQSVTG YNNSVSVTSG FGNKGTGLFS GFMSGFGNTG
     FLQSGFGNLE ANPDNNSATS GFGNSGKQDS GGFNSIDFVS GFFHR