ID   PPE13_MYCTU             Reviewed;         443 AA.
AC   P9WI35; L0T563; Q10540;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=Uncharacterized PPE family protein PPE13;
GN   Name=PPE13; OrderedLocusNames=Rv0878c; ORFNames=MTCY31.06c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43626.1; -; Genomic_DNA.
DR   PIR; C70780; C70780.
DR   RefSeq; WP_003900226.1; NZ_NVQJ01000001.1.
DR   RefSeq; YP_177764.1; NC_000962.3.
DR   AlphaFoldDB; P9WI35; -.
DR   SMR; P9WI35; -.
DR   STRING; 83332.Rv0878c; -.
DR   PaxDb; P9WI35; -.
DR   DNASU; 885617; -.
DR   GeneID; 885617; -.
DR   KEGG; mtu:Rv0878c; -.
DR   TubercuList; Rv0878c; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; VENMGHG; -.
DR   PhylomeDB; P9WI35; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051701; P:biological process involved in interaction with host; IMP:MTBBASE.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR002989; Mycobac_pentapep.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF01469; Pentapeptide_2; 3.
DR   Pfam; PF00823; PPE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..443
FT                   /note="Uncharacterized PPE family protein PPE13"
FT                   /id="PRO_0000217844"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          231..270
FT                   /note="4 X 10 AA approximate repeats"
SQ   SEQUENCE   443 AA;  43592 MW;  C58BEC607F0675E2 CRC64;
     MNFMVLPPEV NSARIYAGAG PAPMLAAAVA WDGLAAELGM AAASFSLLIS GLTAGPGSAW
     QGPAAAAMAA AAAPYLSWLN AATARAEGAA AGAKAAAAVY EAARAATAHP ALVAANRNQL
     LSLVLSNLFG QNLPAIAATE ASYEQLWAQD VAAMVGYHGG ASTVASQLTP WQQLLSVLPP
     VVTAAPAGAV GVPAALAIPA LGVENIGVGN FLGIGNIGNN NVGSGNTGDY NFGIGNIGNA
     NLGNGNIGNA NLGSGNAGFF NFGNGNDGNT NFGSGNAGFL NIGSGNEGSG NLGFGNAGDD
     NTGWGNSGDT NTGGFNSGDL NTGIGSPVTQ GVANSGFGNT GTGHSGFFNS GNSGSGFQNL
     GNGSSGFGNA SDTSSGFQNA GTALTRASST WADSPRAWPI RAPSRLQVWR TRATTARECS
     IRVIISRVSS TGAPPQKKVG NSG