PPE15_MYCTO
ID PPE15_MYCTO Reviewed; 391 AA.
AC P9WI30; L0T5J3; Q79FT5; Q7D8Y7;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 31.
DE RecName: Full=PPE family protein PPE15 {ECO:0000305};
GN Name=PPE15; OrderedLocusNames=MT1068;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- FUNCTION: May play a critical role in the homeostasis of
CC triacylglycerol-containing lipid droplets in M.tuberculosis and
CC influence the entry of the pathogen into a dormant state.
CC {ECO:0000250|UniProtKB:P9WI31}.
CC -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE000516; AAK45319.1; -; Genomic_DNA.
DR PIR; B70625; B70625.
DR RefSeq; WP_003405368.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WI30; -.
DR SMR; P9WI30; -.
DR EnsemblBacteria; AAK45319; AAK45319; MT1068.
DR KEGG; mtc:MT1068; -.
DR PATRIC; fig|83331.31.peg.1147; -.
DR HOGENOM; CLU_000243_0_0_11; -.
DR Proteomes; UP000001020; Chromosome.
DR Gene3D; 1.20.1260.20; -; 1.
DR InterPro; IPR022171; PPE_C.
DR InterPro; IPR000030; PPE_family.
DR InterPro; IPR038332; PPE_sf.
DR Pfam; PF00823; PPE; 1.
DR Pfam; PF12484; PPE-SVP; 1.
PE 3: Inferred from homology;
FT CHAIN 1..391
FT /note="PPE family protein PPE15"
FT /id="PRO_0000428078"
SQ SEQUENCE 391 AA; 38081 MW; AFDF3EA4FB195C4F CRC64;
MDFGALPPEI NSARMYAGAG AGPMMAAGAA WNGLAAELGT TAASYESVIT RLTTESWMGP
ASMAMVAAAQ PYLAWLTYTA EAAAHAGSQA MASAAAYEAA YAMTVPPEVV AANRALLAAL
VATNVLGINT PAIMATEALY AEMWAQDALA MYGYAAASGA AGMLQPLSPP SQTTNPGGLA
AQSAAVGSAA ATAAVNQVSV ADLISSLPNA VSGLASPVTS VLDSTGLSGI IADIDALLAT
PFVANIINSA VNTAAWYVNA AIPTAIFLAN ALNSGAPVAI AEGAIEAAEG AASAAAAGLA
DSVTPAGLGA SLGEATLVGR LSVPAAWSTA APATTAGATA LEGSGWTVAA EEAGPVTGMM
PGMASAAKGT GAYAGPRYGF KPTVMPKQVV V