ID   PPE17_MYCTO             Reviewed;         346 AA.
AC   P9WI26; L0T8M7; Q79FR6; Q7D8Q2;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=PPE family protein PPE17 {ECO:0000250|UniProtKB:P9WI27};
GN   Name=PPE17; OrderedLocusNames=MT1205;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Induces pro-inflammatory responses.
CC       {ECO:0000250|UniProtKB:P9WI27}.
CC   -!- SUBUNIT: Interacts with LRR motifs 15-20 of host Toll-like receptor 2
CC       (TLR2). {ECO:0000250|UniProtKB:P9WI27}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC       {ECO:0000250|UniProtKB:P9WI27}. Cell surface
CC       {ECO:0000250|UniProtKB:P9WI27}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK45462.1; -; Genomic_DNA.
DR   PIR; H70874; H70874.
DR   RefSeq; WP_003898751.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WI26; -.
DR   SMR; P9WI26; -.
DR   EnsemblBacteria; AAK45462; AAK45462; MT1205.
DR   GeneID; 45425140; -.
DR   KEGG; mtc:MT1205; -.
DR   PATRIC; fig|83331.31.peg.1305; -.
DR   HOGENOM; CLU_000243_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR022171; PPE_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
DR   Pfam; PF12484; PPE-SVP; 1.
PE   3: Inferred from homology;
KW   Cell wall; Secreted; Virulence.
FT   CHAIN           1..346
FT                   /note="PPE family protein PPE17"
FT                   /id="PRO_0000428080"
SQ   SEQUENCE   346 AA;  35821 MW;  6DC0844DA6EB9C68 CRC64;
     MDFTIFPPEF NSLNIQGSAR PFLVAANAWK NLSNELSYAA SRFESEINGL ITSWRGPSST
     IMAAAVAPFR AWIVTTASLA ELVADHISVV AGAYEAAHAA HVPLPVIETN RLTRLALATT
     NIFGIHTPAI FALDALYAQY WSQDGEAMNL YATMAAAAAR LTPFSPPAPI ANPGALARLY
     ELIGSVSETV GSFAAPATKN LPSKLWTLLT KGTYPLTAAR ISSIPVEYVL AFVEGSNMGQ
     MMGNLAMRSL TPTLKGPLEL LPNAVRPAVS ATLGNADTIG GLSVPPSWVA DKSITPLAKA
     VPTSAPGGPS GTSWAQLGLA SLAGGAVGAV AARTRSGVIL RSPAAG