PPE20_MYCTO
ID PPE20_MYCTO Reviewed; 539 AA.
AC P9WI22; L0T6I0; Q79FP7; Q7D8H6;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 32.
DE RecName: Full=Uncharacterized PPE family protein PPE20 {ECO:0000250|UniProtKB:P9WI23};
GN Name=PPE20; OrderedLocusNames=MT1431;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WI23}.
CC Note=Secreted via the ESX-3 / type VII secretion system (T7SS).
CC {ECO:0000250|UniProtKB:P9WI23}.
CC -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR EMBL; AE000516; AAK45696.1; -; Genomic_DNA.
DR PIR; A70899; A70899.
DR RefSeq; WP_003407230.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WI22; -.
DR SMR; P9WI22; -.
DR EnsemblBacteria; AAK45696; AAK45696; MT1431.
DR KEGG; mtc:MT1431; -.
DR PATRIC; fig|83331.31.peg.1537; -.
DR HOGENOM; CLU_000243_5_2_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1260.20; -; 1.
DR InterPro; IPR043641; PPE-PPW_C.
DR InterPro; IPR000030; PPE_family.
DR InterPro; IPR038332; PPE_sf.
DR Pfam; PF00823; PPE; 1.
DR Pfam; PF18878; PPE-PPW; 1.
PE 3: Inferred from homology;
KW Secreted.
FT CHAIN 1..539
FT /note="Uncharacterized PPE family protein PPE20"
FT /id="PRO_0000428082"
FT REGION 179..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 55404 MW; 7FE63A9BAC6FBEB5 CRC64;
MTEPWIAFPP EVHSAMLNYG AGVGPMLISA TQNGELSAQY AEAASEVEEL LGVVASEGWQ
GQAAEAFVAA YMPFLAWLIQ ASADCVEMAA QQHVVIEAYT AAVELMPTQV ELAANQIKLA
VLVATNFFGI NTIPIAINEA EYVEMWVRAA TTMATYSTVS RSALSAMPHT SPPPLILKSD
ELLPDTGEDS DEDGHNHGGH SHGGHARMID NFFAEILRGV SAGRIVWDPV NGTLNGLDYD
DYVYPGHAIW WLARGLEFFQ DGEQFGELLF TNPTGAFQFL LYVVVVDLPT HIAQIATWLG
QYPQLLSAAL TGVIAHLGAI TGLAGLSGLS AIPSAAIPAV VPELTPVAAA PPMLAVAGVG
PAVAAPGMLP ASAPAPAAAA GATAAGPTPP ATGFGGFPPY LVGGGGPGIG FGSGQSAHAK
AAASDSAAAE SAAQASARAQ ARAARRGRSA AKARGHRDEF VTMDMGFDAA APAPEHQPGA
RASDCGAGPI GFAGTVRKEA VVKAAGLTTL AGDDFGGGPT MPMMPGTWTH DQGVFDEHR