ID   PPE21_MYCTO             Reviewed;         678 AA.
AC   P9WI20; L0T761; Q10778;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Uncharacterized PPE family protein PPE21;
GN   Name=PPE21; OrderedLocusNames=MT1599;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK45866.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK45866.1; ALT_INIT; Genomic_DNA.
DR   PIR; A70762; A70762.
DR   RefSeq; WP_003903497.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WI20; -.
DR   EnsemblBacteria; AAK45866; AAK45866; MT1599.
DR   KEGG; mtc:MT1599; -.
DR   PATRIC; fig|83331.31.peg.1720; -.
DR   HOGENOM; CLU_000243_4_3_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR002989; Mycobac_pentapep.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF01469; Pentapeptide_2; 8.
DR   Pfam; PF00823; PPE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..678
FT                   /note="Uncharacterized PPE family protein PPE21"
FT                   /id="PRO_0000428083"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   678 AA;  66679 MW;  63344BE7BBD42CF4 CRC64;
     MNFSVLPPEI NSALMFAGAG PGPMLAAASA WTGLAGDLGS AAASFSAVTS QLATGSWQGP
     ASAAMTGVAA SYARWLTTAA AQAEQAAGQA QAAVSAFEAA LAATVHPGAV SANRGRLRSL
     VASNLLGQNA PAIAAVEAVY EQMWAADVAA MLGYHGEASA VALSLTPFTP SPSAAATPGG
     AVIIAGFPFL DLGNVTIGGF NLASGNLGLG NLGSFNPGSA NTGSVNLGNA NIGDLNLGSG
     NIGSYNLGGG NTGDLNPGSG NTGTLNWGSG NIGSYNLGGG NLGSYNLGSG NTGDTNFGGG
     NTGNLNVGGG NTGNSNFGFG NTGNVNFGNG NTGDTNFGSG NLGSGNIGFG NKGSHNIGFG
     NSGNNNIGFG LTGDNQIGFG ALNSGSGNLG FGNSGNGNIG FFNSGNNNIG MGNSGNGVGA
     LSVEFGSSAE RSSGFGNSGE LSTGIGNSGQ LSTGWFNSAT TSTGWFNSGT TNTGWFNSGT
     TNTGIGNSGG NLVTGSMGLF NSGHTNTGSF NAGSMNTGDF NSGNVNTGYF NSGNINTGFF
     NSGDLNTGLF NSVNQPVQNS GWLHTGTNNS GYANAGTFNS GFDNNARDEH AEFVTGNSGL
     ANVGNYNAGI INVGDHLSGF RNSVPTITGT ANISGFVNAG TSISGFFNFG SLMSGFANFD
     DEVSGYLNGD SRASGWIH