ID   PPE21_MYCTU             Reviewed;         678 AA.
AC   P9WI21; L0T761; Q10778;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Uncharacterized PPE family protein PPE21;
GN   Name=PPE21; OrderedLocusNames=Rv1548c; ORFNames=MTCY48.17;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44312.1; -; Genomic_DNA.
DR   PIR; A70762; A70762.
DR   RefSeq; WP_010886120.1; NZ_NVQJ01000004.1.
DR   RefSeq; YP_177817.1; NC_000962.3.
DR   AlphaFoldDB; P9WI21; -.
DR   STRING; 83332.Rv1548c; -.
DR   PaxDb; P9WI21; -.
DR   GeneID; 886384; -.
DR   KEGG; mtu:Rv1548c; -.
DR   TubercuList; Rv1548c; -.
DR   eggNOG; COG3210; Bacteria.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; NEAATTH; -.
DR   PhylomeDB; P9WI21; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR002989; Mycobac_pentapep.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF01469; Pentapeptide_2; 8.
DR   Pfam; PF00823; PPE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..678
FT                   /note="Uncharacterized PPE family protein PPE21"
FT                   /id="PRO_0000217846"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   678 AA;  66737 MW;  209F1593D52533A2 CRC64;
     MNFSVLPPEI NSALMFAGAG PGPMLAAASA WTGLAGDLGS AAASFSAVTS QLATGSWQGP
     ASAAMTGVAA SYARWLTTAA AQAEQAAGQA QAAVSAFEAA LAATVHPGAV SANRGRLRSL
     VASNLLGQNA PAIAAVEAVY EQMWAADVAA MLGYHGEASA VALSLTPFTP SPSAAATPGG
     AVIIAGFPFL DLGNVTIGGF NLASGNLGLG NLGSFNPGSA NTGSVNLGNA NIGDLNLGSG
     NIGSYNLGGG NTGDLNPDSG NTGTLNWGSG NIGSYNLGGG NLGSYNLGSG NTGDTNFGGG
     NTGNLNVGGG NTGNSNFGFG NTGNVNFGNG NTGDTNFGSG NLGSGNIGFG NKGSHNIGFG
     NSGNNNIGFG LTGDNQIGFG ALNSGSGNLG FGNSGNGNIG FFNSGNNNIG MGNSGNGVGA
     LSVEFGSSAE RSSGFGNSGE LSTGIGNSGQ LSTGWFNSAT TSTGWFNSGT TNTGWFNSGT
     TNTGIGNSGG NLVTGSMGLF NSGHTNTGSF NAGSMNTGDF NSGNVNTGYF NSGNINTGFF
     NSGDLNTGLF NSVNQPVQNS GWLHTGTNNS GYANAGTFNS GFDNNARDEH AEFVTGNSGL
     ANVGNYNAGI INVGDHLSGF RNSVPTITGT ANISGFVNAG TSISGFFNFG SLMSGFANFD
     DEVSGYLNGD SRASGWIH