ID   PPE22_MYCTU             Reviewed;         385 AA.
AC   P9WI19; L0T914; Q79FL6; Q8VJZ0;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=Uncharacterized PPE family protein PPE22;
GN   Name=PPE22; OrderedLocusNames=Rv1705c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44470.1; -; Genomic_DNA.
DR   PIR; H70503; H70503.
DR   RefSeq; WP_003898979.1; NZ_NVQJ01000010.1.
DR   RefSeq; YP_177827.1; NC_000962.3.
DR   AlphaFoldDB; P9WI19; -.
DR   SMR; P9WI19; -.
DR   STRING; 83332.Rv1705c; -.
DR   PaxDb; P9WI19; -.
DR   GeneID; 885068; -.
DR   KEGG; mtu:Rv1705c; -.
DR   TubercuList; Rv1705c; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; PATWIDW; -.
DR   PhylomeDB; P9WI19; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR022171; PPE_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
DR   Pfam; PF12484; PPE-SVP; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..385
FT                   /note="Uncharacterized PPE family protein PPE22"
FT                   /id="PRO_0000378478"
SQ   SEQUENCE   385 AA;  38444 MW;  6B2437C16D05024C CRC64;
     MDFGALPPEV NSGRMYCGPG SAPMVAAASA WNGLAAELSV AAVGYERVIT TLQTEEWLGP
     ASTLMVEAVA PYVAWMRATA IQAEQAASQA RAAAAAYETA FAAIVPPPLI AANRARLTSL
     VTHNVFGQNT ASIAATEAQY AEMWAQDAMA MYGYAGSSAT ATKVTPFAPP PNTTSPSAAA
     TQLSAVAKAA GTSAGAAQSA IAELIAHLPN TLLGLTSPLS SALTAAATPG WLEWFINWYL
     PISQLFYNTV GLPYFAIGIG NSLITSWRAL GWIGPEAAEA AAAAPAAVGA AVGGTGPVSA
     GLGNAATIGK LSLPPNWAGA SPSLAPTVGS ASAPLVSDIV EQPEAGAAGN LLGGMPLAGS
     GTGTGGAGPR YGFRVTVMSR PPFAG