ID   PPE23_MYCTU             Reviewed;         394 AA.
AC   P9WI17; L0T7F9; Q79FL5; Q7D842;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 28.
DE   RecName: Full=Uncharacterized PPE family protein PPE23;
GN   Name=PPE23; OrderedLocusNames=Rv1706c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP44471.1; -; Genomic_DNA.
DR   PIR; A70504; A70504.
DR   RefSeq; WP_003898980.1; NZ_NVQJ01000010.1.
DR   RefSeq; YP_177828.1; NC_000962.3.
DR   AlphaFoldDB; P9WI17; -.
DR   SMR; P9WI17; -.
DR   STRING; 83332.Rv1706c; -.
DR   PaxDb; P9WI17; -.
DR   DNASU; 885070; -.
DR   GeneID; 885070; -.
DR   KEGG; mtu:Rv1706c; -.
DR   TubercuList; Rv1706c; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; ELWIELM; -.
DR   PhylomeDB; P9WI17; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR022171; PPE_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
DR   Pfam; PF12484; PPE-SVP; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..394
FT                   /note="Uncharacterized PPE family protein PPE23"
FT                   /id="PRO_0000378479"
SQ   SEQUENCE   394 AA;  39778 MW;  4C991CCAC131A96D CRC64;
     MTLDVPVNQG HVPPGSVACC LVGVTAVADG IAGHSLSNFG ALPPEINSGR MYSGPGSGPL
     MAAAAAWDGL AAELSSAATG YGAAISELTN MRWWSGPASD SMVAAVLPFV GWLSTTATLA
     EQAAMQARAA AAAFEAAFAM TVPPPAIAAN RTLLMTLVDT NWFGQNTPAI ATTESQYAEM
     WAQDAAAMYG YASAAAPATV LTPFAPPPQT TNATGLVGHA TAVAALRGQH SWAAAIPWSD
     IQKYWMMFLG ALATAEGFIY DSGGLTLNAL QFVGGMLWST ALAEAGAAEA AAGAGGAAGW
     SAWSQLGAGP VAASATLAAK IGPMSVPPGW SAPPATPQAQ TVARSIPGIR SAAEAAETSV
     LLRGAPTPGR SRAAHMGRRY GRRLTVMADR PNVG