ID   PPE24_MYCTU             Reviewed;        1053 AA.
AC   P9WI15; L0TAA3; Q79FL2; Q8VJX6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Uncharacterized PPE family protein PPE24;
GN   Name=PPE24; OrderedLocusNames=Rv1753c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44519.1; -; Genomic_DNA.
DR   PIR; B70987; B70987.
DR   RefSeq; WP_010886126.1; NC_018143.2.
DR   RefSeq; YP_177830.1; NC_000962.3.
DR   AlphaFoldDB; P9WI15; -.
DR   STRING; 83332.Rv1753c; -.
DR   PaxDb; P9WI15; -.
DR   GeneID; 885544; -.
DR   KEGG; mtu:Rv1753c; -.
DR   PATRIC; fig|83332.111.peg.1949; -.
DR   TubercuList; Rv1753c; -.
DR   eggNOG; COG5263; Bacteria.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; HPWHRRL; -.
DR   PhylomeDB; P9WI15; -.
DR   Proteomes; UP000001584; Chromosome.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR002989; Mycobac_pentapep.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF01469; Pentapeptide_2; 4.
DR   Pfam; PF00823; PPE; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..1053
FT                   /note="Uncharacterized PPE family protein PPE24"
FT                   /id="PRO_0000378480"
SQ   SEQUENCE   1053 AA;  104650 MW;  A2657C1A1651AF9B CRC64;
     MNFSVLPPEI NSALIFAGAG PEPMAAAATA WDGLAMELAS AAASFGSVTS GLVGGAWQGA
     SSSAMAAAAA PYAAWLAAAA VQAEQTAAQA AAMIAEFEAV KTAVVQPMLV AANRADLVSL
     VMSNLFGQNA PAIAAIEATY EQMWAADVSA MSAYHAGASA IASALSPFSK PLQNLAGLPA
     WLASGAPAAA MTAAAGIPAL AGGPTAINLG IANVGGGNVG NANNGLANIG NANLGNYNFG
     SGNFGNSNIG SASLGNNNIG FGNLGSNNVG VGNLGNLNTG FANTGLGNFG FGNTGNNNIG
     IGLTGNNQIG IGGLNSGTGN FGLFNSGSGN VGFFNSGNGN FGIGNSGNFN TGGWNSGHGN
     TGFFNAGSFN TGMLDVGNAN TGSLNTGSYN MGDFNPGSSN TGTFNTGNAN TGFLNAGNIN
     TGVFNIGHMN NGLFNTGDMN NGVFYRGVGQ GSLQFSITTP DLTLPPLQIP GISVPAFSLP
     AITLPSLNIP AATTPANITV GAFSLPGLTL PSLNIPAATT PANITVGAFS LPGLTLPSLN
     IPAATTPANI TVGAFSLPGL TLPSLNIPAA TTPANITVGA FSLPGLTLPS LNIPAATTPA
     NITVGAFSLP GLTLPSLNIP AATTPANITV SGFQLPPLSI PSVAIPPVTV PPITVGAFNL
     PPLQIPEVTI PQLTIPAGIT IGGFSLPAIH TQPITVGQIG VGQFGLPSIG WDVFLSTPRI
     TVPAFGIPFT LQFQTNVPAL QPPGGGLSTF TNGALIFGEF DLPQLVVHPY TLTGPIVIGS
     FFLPAFNIPG IDVPAINVDG FTLPQITTPA ITTPEFAIPP IGVGGFTLPQ ITTQEIITPE
     LTINSIGVGG FTLPQITTPP ITTPPLTIDP INLTGFTLPQ ITTPPITTPP LTIDPINLTG
     FTLPQITTPP ITTPPLTIEP IGVGGFTTPP LTVPGIHLPS TTIGAFAIPG GPGYFNSSTA
     PSSGFFNSGA GGNSGFGNNG SGLSGWFNTN PAGLLGGSGY QNFGGLSSGF SNLGSGVSGF
     ANRGILPFSV ASVVSGFANI GTNLAGFFQG TTS