ID   PPE26_MYCTU             Reviewed;         393 AA.
AC   Q79FK6; F2GIX6; I6Y7H5; L0T997;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=PPE family protein PPE26 {ECO:0000305};
GN   Name=PPE26 {ECO:0000303|PubMed:26439698, ECO:0000312|EMBL:CCP44555.1};
GN   OrderedLocusNames=Rv1789 {ECO:0000312|EMBL:CCP44555.1};
GN   ORFNames=LH57_09780 {ECO:0000312|EMBL:AIR14538.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RA   Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA   Monaco A., King S., Sohrabi A.;
RT   "Phylogenetic analysis of Mycobacterial species using whole genome
RT   sequences.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [4]
RP   FUNCTION, INTERACTION WITH TLR2, AND BIOTECHNOLOGY.
RX   PubMed=26439698; DOI=10.18632/oncotarget.5956;
RA   Su H., Kong C., Zhu L., Huang Q., Luo L., Wang H., Xu Y.;
RT   "PPE26 induces TLR2-dependent activation of macrophages and drives Th1-type
RT   T-cell immunity by triggering the cross-talk of multiple pathways involved
RT   in the host response.";
RL   Oncotarget 6:38517-38537(2015).
CC   -!- FUNCTION: Probably plays a key role in regulating innate and adaptive
CC       immune responses through human Toll-like receptor 2 (TLR2). Interacts
CC       with TLR2, leading to the subsequent activation of the mitogen-
CC       activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappa-B)
CC       signaling pathways. Stimulates macrophage activation by augmenting pro-
CC       inflammatory cytokine production (TNF-alpha, IL-6 and IL-12p40) and the
CC       expression of cell surface molecules (CD80, CD86, MHC class I and II).
CC       Also participates in adaptive immunity by directing Th1-polarised
CC       immune responses. {ECO:0000269|PubMed:26439698}.
CC   -!- SUBUNIT: Interacts with human TLR2. {ECO:0000269|PubMed:26439698}.
CC   -!- BIOTECHNOLOGY: Candidate for development of a vaccine for the control
CC       of tuberculosis. {ECO:0000269|PubMed:26439698}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44555.1; -; Genomic_DNA.
DR   EMBL; CP009480; AIR14538.1; -; Genomic_DNA.
DR   RefSeq; WP_003408979.1; NZ_NVQJ01000037.1.
DR   RefSeq; YP_177835.1; NC_000962.3.
DR   AlphaFoldDB; Q79FK6; -.
DR   SMR; Q79FK6; -.
DR   STRING; 83332.Rv1789; -.
DR   PaxDb; Q79FK6; -.
DR   DNASU; 885333; -.
DR   GeneID; 885333; -.
DR   KEGG; mtu:Rv1789; -.
DR   PATRIC; fig|83332.111.peg.1993; -.
DR   TubercuList; Rv1789; -.
DR   eggNOG; COG5651; Bacteria.
DR   HOGENOM; CLU_000243_0_1_11; -.
DR   OMA; TVMARPL; -.
DR   PhylomeDB; Q79FK6; -.
DR   PHI-base; PHI:6423; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR022171; PPE_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
DR   Pfam; PF12484; PPE-SVP; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Virulence.
FT   CHAIN           1..393
FT                   /note="PPE family protein PPE26"
FT                   /id="PRO_0000437938"
SQ   SEQUENCE   393 AA;  38589 MW;  D1864B6E54688ABD CRC64;
     MDFGALPPEV NSVRMYAGPG SAPMVAAASA WNGLAAELSS AATGYETVIT QLSSEGWLGP
     ASAAMAEAVA PYVAWMSAAA AQAEQAATQA RAAAAAFEAA FAATVPPPLI AANRASLMQL
     ISTNVFGQNT SAIAAAEAQY GEMWAQDSAA MYAYAGSSAS ASAVTPFSTP PQIANPTAQG
     TQAAAVATAA GTAQSTLTEM ITGLPNALQS LTSPLLQSSN GPLSWLWQIL FGTPNFPTSI
     SALLTDLQPY ASFFYNTEGL PYFSIGMGNN FIQSAKTLGL IGSAAPAAVA AAGDAAKGLP
     GLGGMLGGGP VAAGLGNAAS VGKLSVPPVW SGPLPGSVTP GAAPLPVSTV SAAPEAAPGS
     LLGGLPLAGA GGAGAGPRYG FRPTVMARPP FAG