ID   PPE29_MYCTU             Reviewed;         423 AA.
AC   P9WI09; L0T7Q9; Q79FK1; Q7D7X9;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=Uncharacterized PPE family protein PPE29;
GN   Name=PPE29; OrderedLocusNames=Rv1801;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=16586367; DOI=10.1086/502631;
RA   Jain S.K., Paul-Satyaseela M., Lamichhane G., Kim K.S., Bishai W.R.;
RT   "Mycobacterium tuberculosis invasion and traversal across an in vitro human
RT   blood-brain barrier as a pathogenic mechanism for central nervous system
RT   tuberculosis.";
RL   J. Infect. Dis. 193:1287-1295(2006).
CC   -!- FUNCTION: Could be required for host endothelial-cell invasion and/or
CC       intracellular survival. {ECO:0000269|PubMed:16586367}.
CC   -!- INDUCTION: Highly up-regulated during the early stages of invasion of
CC       the human blood-brain barrier. {ECO:0000269|PubMed:16586367}.
CC   -!- DISRUPTION PHENOTYPE: Invasion of the infant human brain microvascular
CC       endothelial-cell monolayer is significantly decreased in transposon
CC       mutant. {ECO:0000269|PubMed:16586367}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44567.1; -; Genomic_DNA.
DR   PIR; B70931; B70931.
DR   RefSeq; WP_003899026.1; NZ_NVQJ01000037.1.
DR   RefSeq; YP_177840.1; NC_000962.3.
DR   AlphaFoldDB; P9WI09; -.
DR   SMR; P9WI09; -.
DR   STRING; 83332.Rv1801; -.
DR   PaxDb; P9WI09; -.
DR   DNASU; 885491; -.
DR   GeneID; 885491; -.
DR   KEGG; mtu:Rv1801; -.
DR   TubercuList; Rv1801; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; NWYQIAL; -.
DR   PhylomeDB; P9WI09; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR022171; PPE_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
DR   Pfam; PF12484; PPE-SVP; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..423
FT                   /note="Uncharacterized PPE family protein PPE29"
FT                   /id="PRO_0000378481"
SQ   SEQUENCE   423 AA;  41477 MW;  26E52CC271FBBF57 CRC64;
     MDFGLLPPEI NSGRMYTGPG PGPMLAAATA WDGLAVELHA TAAGYASELS ALTGAWSGPS
     STSMASAAAP YVAWMSATAV HAELAGAQAR LAIAAYEAAF AATVPPPVIA ANRAQLMVLI
     ATNIFGQNTP AIMMTEAQYM EMWAQDAAAM YGYAGSSATA SRMTAFTEPP QTTNHGQLGA
     QSSAVAQTAA TAAGGNLQSA FPQLLSAVPR ALQGLALPTA SQSASATPQW VTDLGNLSTF
     LGGAVTGPYT FPGVLPPSGV PYLLGIQSVL VTQNGQGVSA LLGKIGGKPI TGALAPLAEF
     ALHTPILGSE GLGGGSVSAG IGRAGLVGKL SVPQGWTVAA PEIPSPAAAL QATRLAAAPI
     AATDGAGALL GGMALSGLAG RAAAGSTGHP IGSAAAPAVG AAAAAVEDLA TEANIFVIPA
     MDD