ID   PPE34_MYCTU             Reviewed;        1459 AA.
AC   Q79FI9; I6XCU7; L0TAZ1;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=PPE family protein PPE34 {ECO:0000305};
GN   Name=PPE34 {ECO:0000312|EMBL:CCP44684.1};
GN   OrderedLocusNames=Rv1917c {ECO:0000312|EMBL:CCP44684.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=H37Rv;
RX   PubMed=11800581; DOI=10.1054/tube.2001.0304;
RA   Sampson S.L., Lukey P., Warren R.M., van Helden P.D., Richardson M.,
RA   Everett M.J.;
RT   "Expression, characterization and subcellular localization of the
RT   Mycobacterium tuberculosis PPE gene Rv1917c.";
RL   Tuberculosis 81:305-317(2001).
RN   [3]
RP   FUNCTION, INTERACTION WITH TLR2, AND SUBCELLULAR LOCATION.
RX   PubMed=20837474; DOI=10.1074/jbc.m110.158055;
RA   Bansal K., Sinha A.Y., Ghorpade D.S., Togarsimalemath S.K., Patil S.A.,
RA   Kaveri S.V., Balaji K.N., Bayry J.;
RT   "Src homology 3-interacting domain of Rv1917c of Mycobacterium tuberculosis
RT   induces selective maturation of human dendritic cells by regulating PI3K-
RT   MAPK-NF-kappaB signaling and drives Th2 immune responses.";
RL   J. Biol. Chem. 285:36511-36522(2010).
CC   -!- FUNCTION: Facilitates a shift in the ensuing immunity toward the Th2
CC       phenotype and could aid in immune evasion by mycobacteria. Interacts
CC       with human Toll-like receptor 2 (TLR2) and triggers functional
CC       maturation of human dendritic cells (DCs), leading to secretion of IL-
CC       4, IL-5 and IL-10 from CD4(+) T cells and induction of Th2 immune
CC       response. Maturation of DCs involves PI3K, ERK1/2, p38 MAPK and NF-
CC       kappa-B signaling pathways. {ECO:0000269|PubMed:20837474}.
CC   -!- SUBUNIT: Interacts with human TLR2. {ECO:0000269|PubMed:20837474}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20837474}.
CC       Secreted, cell wall {ECO:0000269|PubMed:11800581,
CC       ECO:0000269|PubMed:20837474}. Cell surface
CC       {ECO:0000269|PubMed:11800581}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44684.1; -; Genomic_DNA.
DR   RefSeq; WP_010886134.1; NC_018143.2.
DR   RefSeq; YP_177655.1; NC_000962.3.
DR   AlphaFoldDB; Q79FI9; -.
DR   STRING; 83332.Rv1917c; -.
DR   PaxDb; Q79FI9; -.
DR   GeneID; 885362; -.
DR   KEGG; mtu:Rv1917c; -.
DR   PATRIC; fig|83332.111.peg.2132; -.
DR   TubercuList; Rv1917c; -.
DR   eggNOG; COG5263; Bacteria.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; ANRMIST; -.
DR   PhylomeDB; Q79FI9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0052553; P:modulation by symbiont of host immune response; IDA:MTBBASE.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR002989; Mycobac_pentapep.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF01469; Pentapeptide_2; 10.
DR   Pfam; PF00823; PPE; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Cell wall; Membrane; Reference proteome; Secreted;
KW   Virulence.
FT   CHAIN           1..1459
FT                   /note="PPE family protein PPE34"
FT                   /id="PRO_0000437939"
SQ   SEQUENCE   1459 AA;  142944 MW;  174F54ED439B579E CRC64;
     MNFSTLPPEI NSALIFGGAG SEPMSAAAVA WDQLAMELAS AAASFNSVTS GLVGESWLGP
     SSAAMAAAVA PYLGWLAAAA AQAQRSATQA AALVAEFEAV RAAMVQPALV AANRSDLVSL
     VFSNFFGQNA PAIAAIEAAY EQMWAIDVSV MSAYHAGASA VASALTPFTA PPQNLTDLPA
     QLAAAPAAVV TAAITSSKGV LANLSLGLAN SGFGQMGAAN LGILNLGSLN PGGNNFGLGN
     VGSNNVGLGN TGNGNIGFGN TGNGNIGFGL TGDNQQGFGG WNSGTGNIGL FNSGTGNIGI
     GNTGTGNFGI GNSGTSYNTG IGNTGQANTG FFNAGIANTG IGNTGNYNTG SFNLGSFNTG
     DFNTGSSNTG FFNPGNLNTG VGNTGNVNTG GFNSGNYSNG FFWRGDYQGL IGFSGTLTIP
     AAGLDLNGLG SVGPITIPSI TIPEIGLGIN SSGALVGPIN VPPITVPAIG LGINSTGALV
     GPINIPPITL NSIGLELSAF QVINVGSISI PASPLAIGLF GVNPTVGSIG PGSISIQLGT
     PEIPAIPPFF PGFPPDYVTV SGQIGPITFL SGGYSLPAIP LGIDVGGGLG PFTVFPDGYS
     LPAIPLGIDV GGGLGPFTVF PDGYSLPAIP LGIDVGGGLG PFTVFPDGYS LPAIPLGIDV
     GGAIGPLTTP PITIPSIPLG IDVSGSLGPI NIPIEIAGTP GFGNSTTTPS SGFFNSGTGG
     TSGFGNVGSG GSGFWNIAGN LGNSGFLNVG PLTSGILNFG NTVSGLYNTS TLGLATSAFH
     SGVGNTDSQL AGFMRNAAGG TLFNFGFAND GTLNLGNANL GDYNVGSGNV GSYNFGSGNI
     GNGSFGFGNI GSNNFGFGNV GSNNLGFANT GPGLTEALHN IGFGNIGGNN YGFANIGNGN
     IGFGNTGTGN IGIGLTGDNQ VGFGALNSGS GNIGFFNSGN GNIGFFNSGN GNVGIGNSGN
     YNTGLGNVGN ANTGLFNTGN VNTGIGNAGS YNTGSYNAGD TNTGDLNPGN ANTGYLNLGD
     LNTGWGNIGD LNTGALISGS YSNGILWRGD YQGLIGYSDT LSIPAIPLSV EVNGGIGPIV
     VPDITIPGIP LSLNALGGVG PIVVPDITIP GIPLSLNALG GVGPIVVPDI TIPGIPLSLN
     ALGGVGPIVV PDITIPGIPL SLNALGGVGP IVVPDITIPG IPLSLNALGG VGPITVPGVP
     ISRIPLTINI RIPVNITLNE LPFNVAGIFT GYIGPIPLST FVLGVTLAGG TLESGIQGFS
     VNPFGLNIPL SGATNAVTIP GFAINPFGLN VPLSGGTSPV TIPGFAINPF GLNVPLSGGT
     SPVTIPGFTI PGSPLNLTAN GGLGPINIPI NITSAPGFGN STTTPSSGFF NSGDGSASGF
     GNVGPGISGL WNQVPNALQG GVSGIYNVGQ LASGVANLGN TVSGFNNTST VGHLTAAFNS
     GVNNIGQMLL GFFSPGAGP