ID   PPE36_MYCTU             Reviewed;         243 AA.
AC   P9WI01; L0TA84; P95315; Q79FH5; Q7D7I4;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 30.
DE   RecName: Full=Uncharacterized PPE family protein PPE36;
GN   Name=PPE36; Synonyms=p27; OrderedLocusNames=Rv2108;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=10970728; DOI=10.1006/mcpr.2000.0310;
RA   Chevrier D., Casademont I., Guesdon J.-L.;
RT   "Cloning of a gene from Mycobacterium tuberculosis coding for a
RT   hypothetical 27 kDa protein and its use for the specific PCR identification
RT   of these mycobacteria.";
RL   Mol. Cell. Probes 14:241-248(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [3]
RP   PROTEIN SEQUENCE OF N-TERMINUS, EXPRESSION, AND SUBCELLULAR LOCATION.
RX   PubMed=15958258; DOI=10.1016/j.tube.2005.02.002;
RA   Le Moigne V., Robreau G., Borot C., Guesdon J.-L., Mahana W.;
RT   "Expression, immunochemical characterization and localization of the
RT   Mycobacterium tuberculosis protein p27.";
RL   Tuberculosis 85:213-219(2005).
RN   [4]
RP   PROTEIN SEQUENCE OF N-TERMINUS, AND EXPRESSION.
RX   PubMed=18289677; DOI=10.1016/j.molimm.2008.01.005;
RA   Le Moigne V., Robreau G., Mahana W.;
RT   "Flagellin as a good carrier and potent adjuvant for Th1 response: study of
RT   mice immune response to the p27 (Rv2108) Mycobacterium tuberculosis
RT   antigen.";
RL   Mol. Immunol. 45:2499-2507(2008).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15958258}.
CC   -!- MISCELLANEOUS: Protein expressed in vitro is immunologically active and
CC       reacts with antibodies from tuberculosis patient sera. Could provide a
CC       specific complimentary diagnostic test for the presence of and
CC       infection with M.tuberculosis.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; U88049; AAB47769.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP44883.1; -; Genomic_DNA.
DR   PIR; G70511; G70511.
DR   RefSeq; WP_003900467.1; NZ_NVQJ01000058.1.
DR   RefSeq; YP_177859.1; NC_000962.3.
DR   AlphaFoldDB; P9WI01; -.
DR   SMR; P9WI01; -.
DR   STRING; 83332.Rv2108; -.
DR   PaxDb; P9WI01; -.
DR   DNASU; 887814; -.
DR   GeneID; 887814; -.
DR   KEGG; mtu:Rv2108; -.
DR   TubercuList; Rv2108; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; METYWEA; -.
DR   PhylomeDB; P9WI01; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Membrane; Reference proteome.
FT   CHAIN           1..243
FT                   /note="Uncharacterized PPE family protein PPE36"
FT                   /id="PRO_0000379113"
SQ   SEQUENCE   243 AA;  27480 MW;  0BAFBA0EF63B99BA CRC64;
     MPNFWALPPE INSTRIYLGP GSGPILAAAQ GWNALASELE KTKVGLQSAL DTLLESYRGQ
     SSQALIQQTL PYVQWLTTTA EHAHKTAIQL TAAANAYEQA RAAMVPPAMV RANRVQTTVL
     KAINWFGQFS TRIADKEADY EQMWFQDALV MENYWEAVQE AIQSTSHFED PPEMADDYDE
     AWMLNTVFDY HNENAKEEVI HLVPDVNKER GPIELVTKVD KEGTIRLVYD GEPTFSYKEH
     PKF