ID   PPE37_MYCTU             Reviewed;         473 AA.
AC   Q79FH3; L0TA95;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Uncharacterized PPE family protein PPE37;
GN   Name=PPE37; OrderedLocusNames=Rv2123;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION.
RX   PubMed=16113319; DOI=10.1128/iai.73.9.5988-5994.2005;
RA   Manabe Y.C., Hatem C.L., Kesavan A.K., Durack J., Murphy J.R.;
RT   "Both Corynebacterium diphtheriae DtxR(E175K) and Mycobacterium
RT   tuberculosis IdeR(D177K) are dominant positive repressors of IdeR-regulated
RT   genes in M. tuberculosis.";
RL   Infect. Immun. 73:5988-5994(2005).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- INDUCTION: Transcriptionally regulated by IdeR.
CC       {ECO:0000269|PubMed:16113319}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44898.1; -; Genomic_DNA.
DR   PIR; F70513; F70513.
DR   RefSeq; WP_003411053.1; NZ_NVQJ01000058.1.
DR   RefSeq; YP_177861.1; NC_000962.3.
DR   AlphaFoldDB; Q79FH3; -.
DR   SMR; Q79FH3; -.
DR   STRING; 83332.Rv2123; -.
DR   PaxDb; Q79FH3; -.
DR   GeneID; 888710; -.
DR   KEGG; mtu:Rv2123; -.
DR   TubercuList; Rv2123; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; IPIAFNE; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0052572; P:response to host immune response; IEP:MTBBASE.
DR   GO; GO:0075139; P:response to host iron concentration; IMP:MTBBASE.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR043641; PPE-PPW_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
DR   Pfam; PF18878; PPE-PPW; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..473
FT                   /note="Uncharacterized PPE family protein PPE37"
FT                   /id="PRO_0000379114"
SQ   SEQUENCE   473 AA;  48563 MW;  1B606F8C3D08555B CRC64;
     MTFPMWFAVP PEVPSAWLST GMGPGPLLAA ARAWHALAAQ YTEIATELAS VLAAVQASSW
     QGPSADRFVV AHQPFRYWLT HAATVATAAA AAHETAAAGY TSALGGMPTL AELAANHAMH
     GALVTTNFFG VNTIPIALNE ADYLRMWIQA ATVMSHYQAV AHESVAATPS TPPAPQIVTS
     AASSAASSSF PDPTKLILQL LKDFLELLRY LAVELLPGPL GDLIAQVLDW FISFVSGPVF
     TFLAYLVLDP LIYFGPFAPL TSPVLLPAGL TGLAGLGAVS GPAGPMVERV HSDGPSRQSW
     PAATGVTLVG TNPAALVTTP APAPTTSAAP TAPSTPGSSA AQGLYAVGGP DGEGFNPIAK
     TTALAGVTTD AAAPAAKLPG DQAQSSASKA TRLRRRLRQH RFEFLADDGR LTMPNTPEMA
     DVAAGNRGLD ALGFAGTIPK SAPGSATGLT HLGGGFADVL SQPMLPHTWD GSD