ID   PPE42_MYCTU             Reviewed;         580 AA.
AC   P9WHZ5; L0TA57; Q79FC6; Q7D6W9;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Uncharacterized PPE family protein PPE42;
GN   Name=PPE42; OrderedLocusNames=Rv2608;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15346333; DOI=10.1086/423938;
RA   Chakhaiyar P., Nagalakshmi Y., Aruna B., Murthy K.J.R., Katoch V.M.,
RA   Hasnain S.E.;
RT   "Regions of high antigenicity within the hypothetical PPE major polymorphic
RT   tandem repeat open-reading frame, Rv2608, show a differential humoral
RT   response and a low T cell response in various categories of patients with
RT   tuberculosis.";
RL   J. Infect. Dis. 190:1237-1244(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Elicits a high humoral and a low T-cell response. Could be
CC       involved in directing the host toward development of a more humoral
CC       type of immune response. {ECO:0000269|PubMed:15346333}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during infection of the host.
CC       {ECO:0000269|PubMed:15346333}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45405.1; -; Genomic_DNA.
DR   PIR; G70570; G70570.
DR   RefSeq; WP_003899395.1; NZ_NVQJ01000023.1.
DR   RefSeq; YP_177893.1; NC_000962.3.
DR   AlphaFoldDB; P9WHZ5; -.
DR   SMR; P9WHZ5; -.
DR   STRING; 83332.Rv2608; -.
DR   ESTHER; myctu-ppe42; PE-PPE.
DR   PaxDb; P9WHZ5; -.
DR   DNASU; 888204; -.
DR   GeneID; 888204; -.
DR   KEGG; mtu:Rv2608; -.
DR   TubercuList; Rv2608; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; ILIPTHD; -.
DR   PhylomeDB; P9WHZ5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0052559; P:induction by symbiont of host immune response; IDA:MTBBASE.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013228; PE-PPE_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF08237; PE-PPE; 1.
DR   Pfam; PF00823; PPE; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..580
FT                   /note="Uncharacterized PPE family protein PPE42"
FT                   /id="PRO_0000379116"
FT   DOMAIN          300..525
FT                   /note="PE-PPE"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   580 AA;  59675 MW;  C9CEC4D15CEEB4E2 CRC64;
     MNFAVLPPEV NSARIFAGAG LGPMLAAASA WDGLAEELHA AAGSFASVTT GLAGDAWHGP
     ASLAMTRAAS PYVGWLNTAA GQAAQAAGQA RLAASAFEAT LAATVSPAMV AANRTRLASL
     VAANLLGQNA PAIAAAEAEY EQIWAQDVAA MFGYHSAASA VATQLAPIQE GLQQQLQNVL
     AQLASGNLGS GNVGVGNIGN DNIGNANIGF GNRGDANIGI GNIGDRNLGI GNTGNWNIGI
     GITGNGQIGF GKPANPDVLV VGNGGPGVTA LVMGGTDSLL PLPNIPLLEY AARFITPVHP
     GYTATFLETP SQFFPFTGLN SLTYDVSVAQ GVTNLHTAIM AQLAAGNEVV VFGTSQSATI
     ATFEMRYLQS LPAHLRPGLD ELSFTLTGNP NRPDGGILTR FGFSIPQLGF TLSGATPADA
     YPTVDYAFQY DGVNDFPKYP LNVFATANAI AGILFLHSGL IALPPDLASG VVQPVSSPDV
     LTTYILLPSQ DLPLLVPLRA IPLLGNPLAD LIQPDLRVLV ELGYDRTAHQ DVPSPFGLFP
     DVDWAEVAAD LQQGAVQGVN DALSGLGLPP PWQPALPRLF