ID   PPE44_MYCTU             Reviewed;         382 AA.
AC   P9WHZ3; L0TC75; Q79FA7; Q7D6M0;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Uncharacterized PPE family protein PPE44;
GN   Name=PPE44; OrderedLocusNames=Rv2770c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   EXPRESSION, AND POTENTIAL USE AS A VACCINE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=18822333; DOI=10.1016/j.vaccine.2008.09.025;
RA   Romano M., Rindi L., Korf H., Bonanni D., Adnet P.-Y., Jurion F.,
RA   Garzelli C., Huygen K.;
RT   "Immunogenicity and protective efficacy of tuberculosis subunit vaccines
RT   expressing PPE44 (Rv2770c).";
RL   Vaccine 26:6053-6063(2008).
CC   -!- MISCELLANEOUS: Protective antigen that could be included in novel
CC       subunit tuberculosis vaccines. Expressed and presented to the immune
CC       system throughout the different stages of the infection
CC       (PubMed:18822333). {ECO:0000305|PubMed:18822333}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45569.1; -; Genomic_DNA.
DR   PIR; A70882; A70882.
DR   RefSeq; WP_003906903.1; NZ_NVQJ01000020.1.
DR   RefSeq; YP_177677.1; NC_000962.3.
DR   AlphaFoldDB; P9WHZ3; -.
DR   SMR; P9WHZ3; -.
DR   STRING; 83332.Rv2770c; -.
DR   PaxDb; P9WHZ3; -.
DR   DNASU; 888456; -.
DR   GeneID; 888456; -.
DR   KEGG; mtu:Rv2770c; -.
DR   TubercuList; Rv2770c; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; NSARMYF; -.
DR   PhylomeDB; P9WHZ3; -.
DR   PHI-base; PHI:9051; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR022171; PPE_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
DR   Pfam; PF12484; PPE-SVP; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..382
FT                   /note="Uncharacterized PPE family protein PPE44"
FT                   /id="PRO_0000379590"
SQ   SEQUENCE   382 AA;  37467 MW;  659690A2C0B1D6F9 CRC64;
     MDFGALPPEV NSARMYGGAG AADLLAAAAA WNGIAVEVST AASSVGSVIT RLSTEHWMGP
     ASLSMAAAVQ PYLVWLTCTA ESSALAAAQA MASAAAFETA FALTVPPAEV VANRALLAEL
     TATNILGQNV SAIAATEARY GEMWAQDASA MYGYAAASAV AARLNPLTRP SHITNPAGLA
     HQAAAVGQAG ASAFARQVGL SHLISDVADA VLSFASPVMS AADTGLEAVR QFLNLDVPLF
     VESAFHGLGG VADFATAAIG NMTLLADAMG TVGGAAPGGG AAAAVAHAVA PAGVGGTALT
     ADLGNASVVG RLSVPASWST AAPATAAGAA LDGTGWAVPE EDGPIAVMPP APGMVVAANS
     VGADSGPRYG VKPIVMPKHG LF