ID   PPE45_MYCBO             Reviewed;         408 AA.
AC   P0A695; A0A1R3Y2N1; Q10813; X2BM47;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Uncharacterized PPE family protein PPE45;
GN   Name=PPE45; OrderedLocusNames=BQ2027_MB2916C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; LT708304; SIU01537.1; -; Genomic_DNA.
DR   RefSeq; NP_856561.1; NC_002945.3.
DR   RefSeq; WP_003414680.1; NC_002945.4.
DR   AlphaFoldDB; P0A695; -.
DR   SMR; P0A695; -.
DR   EnsemblBacteria; SIU01537; SIU01537; BQ2027_MB2916C.
DR   PATRIC; fig|233413.5.peg.3200; -.
DR   OMA; VAXLSAT; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR022171; PPE_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
DR   Pfam; PF12484; PPE-SVP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..408
FT                   /note="Uncharacterized PPE family protein PPE45"
FT                   /id="PRO_0000217849"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   408 AA;  41469 MW;  3E3D1F20D7827199 CRC64;
     MDFGVLPPEI NSGRMYAGPG SGPMMAAAAA WDSLAAELGL AAGGYRLAIS ELTGAYWAGP
     AAASMVAAVT PYVAWLSATA GQAEQAGMQA RAAAAAYELA FAMTVPPPVV VANRALLVAL
     VATNFFGQNT PAIAATEAQY AEMWAQDAAA MYAYAGSAAI ATELTPFTAA PVTTSPAALA
     GQAAATVSST VPPLATTAAV PQLLQQLSST SLIPWYSALQ QWLAENLLGL TPDNRMTIVR
     LLGISYFDEG LLQFEASLAQ QAIPGTPGGA GDSGSSVLDS WGPTIFAGPR ASPSVAGGGA
     VGGVQTPQPY WYWALDRESI GGSVSAALGK GSSAGSLSVP PDWAARARWA NPAAWRLPGD
     DVTALRGTAE NALLRGFPMA SAGQSTGGGF VHKYGFRLAV MQRPPFAG