ID   PPE45_MYCTU             Reviewed;         408 AA.
AC   P9WHZ1; L0TCJ6; P0A694; Q10813;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Uncharacterized PPE family protein PPE45;
GN   Name=PPE45; OrderedLocusNames=Rv2892c; ORFNames=MTCY274.23c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45694.1; -; Genomic_DNA.
DR   PIR; G70925; G70925.
DR   RefSeq; WP_003414680.1; NZ_NVQJ01000006.1.
DR   RefSeq; YP_177913.1; NC_000962.3.
DR   AlphaFoldDB; P9WHZ1; -.
DR   SMR; P9WHZ1; -.
DR   STRING; 83332.Rv2892c; -.
DR   PaxDb; P9WHZ1; -.
DR   DNASU; 887824; -.
DR   GeneID; 887824; -.
DR   KEGG; mtu:Rv2892c; -.
DR   PATRIC; fig|83332.111.peg.3219; -.
DR   TubercuList; Rv2892c; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; VAXLSAT; -.
DR   PhylomeDB; P9WHZ1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR022171; PPE_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
DR   Pfam; PF12484; PPE-SVP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..408
FT                   /note="Uncharacterized PPE family protein PPE45"
FT                   /id="PRO_0000217850"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   408 AA;  41469 MW;  3E3D1F20D7827199 CRC64;
     MDFGVLPPEI NSGRMYAGPG SGPMMAAAAA WDSLAAELGL AAGGYRLAIS ELTGAYWAGP
     AAASMVAAVT PYVAWLSATA GQAEQAGMQA RAAAAAYELA FAMTVPPPVV VANRALLVAL
     VATNFFGQNT PAIAATEAQY AEMWAQDAAA MYAYAGSAAI ATELTPFTAA PVTTSPAALA
     GQAAATVSST VPPLATTAAV PQLLQQLSST SLIPWYSALQ QWLAENLLGL TPDNRMTIVR
     LLGISYFDEG LLQFEASLAQ QAIPGTPGGA GDSGSSVLDS WGPTIFAGPR ASPSVAGGGA
     VGGVQTPQPY WYWALDRESI GGSVSAALGK GSSAGSLSVP PDWAARARWA NPAAWRLPGD
     DVTALRGTAE NALLRGFPMA SAGQSTGGGF VHKYGFRLAV MQRPPFAG