ID   PPE47_MYCTU             Reviewed;         435 AA.
AC   P9WHY7; L0TE35; O53268; O53269;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 27.
DE   RecName: Full=Uncharacterized PPE family protein PPE47/PPE48;
GN   Name=PPE47/ppe48; OrderedLocusNames=Rv3021c/Rv3022c;
GN   ORFNames=MTV012.35c/MTV012.36c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=16586367; DOI=10.1086/502631;
RA   Jain S.K., Paul-Satyaseela M., Lamichhane G., Kim K.S., Bishai W.R.;
RT   "Mycobacterium tuberculosis invasion and traversal across an in vitro human
RT   blood-brain barrier as a pathogenic mechanism for central nervous system
RT   tuberculosis.";
RL   J. Infect. Dis. 193:1287-1295(2006).
CC   -!- INDUCTION: Highly up-regulated during the early stages of invasion of
CC       the human blood-brain barrier. {ECO:0000269|PubMed:16586367}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCP45828.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AL123456; CCP45828.1; ALT_FRAME; Genomic_DNA.
DR   AlphaFoldDB; P9WHY7; -.
DR   SMR; P9WHY7; -.
DR   STRING; 83332.Rv3022c; -.
DR   PaxDb; P9WHY7; -.
DR   TubercuList; Rv3021c; -.
DR   TubercuList; Rv3022c; -.
DR   eggNOG; COG5651; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR043641; PPE-PPW_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
DR   Pfam; PF18878; PPE-PPW; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..435
FT                   /note="Uncharacterized PPE family protein PPE47/PPE48"
FT                   /id="PRO_0000217852"
SQ   SEQUENCE   435 AA;  42877 MW;  3B157643EAA8484A CRC64;
     MTAPVWLASP PEVHSALLSA GPGPGSLQAA AAGWSALSAE YAAVAQELSV VVAAVGAGVW
     QGPSAELFVA AYVPYVAWLV QASADSAAAA GEHEAAAAGY VCALAEMPTL PELAANHLTH
     AVLVATNFFG INTIPIALNE ADYVRMWVQA ATVMSAYEAV VGAALVATPH TGPAPVIVKP
     GANEASNAVA AATITPFPFG ELAKFLEMAA QAFTEVGELI MKSAEAWAVG FVELITGLVN
     FEPWLVLTGM IDMFFATVGF ALGVFVLVPL LEFAVVLELA ILSIGWIISN IFGAIPVLGG
     PLLGALAAAV VPGVAGLAGV AGLAALPAVG AAAGAPAALV GSVAPVSGGV VSPQARLVSA
     VEPAPASTSV SVLASDRGAG ALGFVGTAGK ESVGQPAGLT VLADEFGDGA PVPMLPGSWG
     PDLVGVAGDG GLVSV