ID   PPE50_MYCTU             Reviewed;         132 AA.
AC   Q6MX07; L0TEE9;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Uncharacterized PPE family protein PPE50;
GN   Name=PPE50; OrderedLocusNames=Rv3135;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45945.1; -; Genomic_DNA.
DR   PIR; H70645; H70645.
DR   RefSeq; WP_003906988.1; NC_000962.3.
DR   RefSeq; YP_177934.1; NC_000962.3.
DR   AlphaFoldDB; Q6MX07; -.
DR   SMR; Q6MX07; -.
DR   STRING; 83332.Rv3135; -.
DR   PaxDb; Q6MX07; -.
DR   DNASU; 888153; -.
DR   GeneID; 888153; -.
DR   KEGG; mtu:Rv3135; -.
DR   TubercuList; Rv3135; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; MQAPTGL; -.
DR   PhylomeDB; Q6MX07; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..132
FT                   /note="Uncharacterized PPE family protein PPE50"
FT                   /id="PRO_0000378484"
SQ   SEQUENCE   132 AA;  13667 MW;  14CAF20BDFAAA293 CRC64;
     MDYAFLPPEI NSARMYSGPG PNSMLVAAAS WDALAAELAS AAENYGSVIA RLTGMHWWGP
     ASTSMLAMSA PYVEWLERTA AQTKQTATQA RAAAAAFEQA HAMTVPPALV TGIRGAIVVE
     TASASNTAGT PP