ID   PPE63_MYCTU             Reviewed;         479 AA.
AC   P9WHX5; L0TFR2; Q6MWW1; Q7D5B9;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=Uncharacterized PPE family protein PPE63;
GN   Name=PPE63; OrderedLocusNames=Rv3539;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP46361.1; -; Genomic_DNA.
DR   PIR; D70676; D70676.
DR   RefSeq; WP_003900090.1; NZ_NVQJ01000014.1.
DR   RefSeq; YP_177987.1; NC_000962.3.
DR   AlphaFoldDB; P9WHX5; -.
DR   SMR; P9WHX5; -.
DR   STRING; 83332.Rv3539; -.
DR   ESTHER; myctu-ppe63; PE-PPE.
DR   PaxDb; P9WHX5; -.
DR   DNASU; 888438; -.
DR   GeneID; 888438; -.
DR   KEGG; mtu:Rv3539; -.
DR   TubercuList; Rv3539; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; TTMYMIP; -.
DR   PhylomeDB; P9WHX5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0052572; P:response to host immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013228; PE-PPE_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF08237; PE-PPE; 1.
DR   Pfam; PF00823; PPE; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..479
FT                   /note="Uncharacterized PPE family protein PPE63"
FT                   /id="PRO_0000379118"
FT   DOMAIN          240..462
FT                   /note="PE-PPE"
FT                   /evidence="ECO:0000255"
FT   REGION          180..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   479 AA;  49970 MW;  271745FB45473C92 CRC64;
     MADFLTLSPE VNSARMYAGG GPGSLSAAAA AWDELAAELW LAAASFESVC SGLADRWWQG
     PSSRMMAAQA ARHTGWLAAA ATQAEGAASQ AQTMALAYEA AFAATVHPAL VAANRALVAW
     LAGSNVFGQN TPAIAAAEAI YEQMWAQDVV AMLNYHAVAS AVGARLRPWQ QLLHELPRRL
     GGEHSDSTNT ELANPSSTTT RITVPGASPV HAATLLPFIG RLLAARYAEL NTAIGTNWFP
     GTTPEVVSYP ATIGVLSGSL GAVDANQSIA IGQQMLHNEI LAATASGQPV TVAGLSMGSM
     VIDRELAYLA IDPNAPPSSA LTFVELAGPE RGLAQTYLPV GTTIPIAGYT VGNAPESQYN
     TSVVYSQYDI WADPPDRPWN LLAGANALMG AAYFHDLTAY AAPQQGIEIA AVTSSLGGTT
     TTYMIPSPTL PLLLPLKQIG VPDWIVGGLN NVLKPLVDAG YSQYAPTAGP YFSHGNLVW