ID   PPE66_MYCTU             Reviewed;         315 AA.
AC   P9WHX1; L0TGL5; Q79FA3;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Uncharacterized PPE family protein PPE66;
GN   Name=PPE66; OrderedLocusNames=Rv3738c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP46565.1; -; Genomic_DNA.
DR   PIR; C70798; C70798.
DR   RefSeq; WP_003899661.1; NC_000962.3.
DR   RefSeq; YP_178009.1; NC_000962.3.
DR   AlphaFoldDB; P9WHX1; -.
DR   SMR; P9WHX1; -.
DR   STRING; 83332.Rv3738c; -.
DR   PaxDb; P9WHX1; -.
DR   DNASU; 886262; -.
DR   GeneID; 886262; -.
DR   KEGG; mtu:Rv3738c; -.
DR   PATRIC; fig|83332.111.peg.4158; -.
DR   TubercuList; Rv3738c; -.
DR   eggNOG; COG5651; Bacteria.
DR   OMA; INHAAHA; -.
DR   PhylomeDB; P9WHX1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR043641; PPE-PPW_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
DR   Pfam; PF18878; PPE-PPW; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..315
FT                   /note="Uncharacterized PPE family protein PPE66"
FT                   /id="PRO_0000379592"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   315 AA;  31436 MW;  C6C34AE0D5689F79 CRC64;
     MTTAYASALA AMPTLTELAA NHTSHAVLLG TNFFGINTIP IALNEADYAR MWIQAATTMS
     IYEGTSDAAL ASAPQTTPAP VLFNGGAGVA SALPAISAAT LDPASIIGII IEILIQLFLI
     SLEILFAIVA YTIIIVLILP LVIFAYAIVF AVLAIIFGPP LLVIASPFVL TGSVIAVPTS
     LSTSLSTAVP IGVGQYLADL ASADAQAIEV GLKTADVAPV AVRPAAAPPL RESAAVRPEA
     RLVSAVAPAP AGTSASVLAS DRGAGVLGFA GTAGKESVGR PAGLTTLAGG EFGGSPSVPM
     VPASWEQLVG AGEAG