ID   PPE68_MYCTO             Reviewed;         368 AA.
AC   P9WHW8; L0TFI2; Q79F92; Q7D4P4;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=PPE family immunomodulator PPE68 {ECO:0000250|UniProtKB:P9WHW9};
GN   Name=PPE68; OrderedLocusNames=MT3987;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Plays a major role in RD1-associated pathogenesis, and may
CC       contribute to the establishment and maintenance of M.tuberculosis
CC       infection. Together with PE35, stimulates the secretion of IL-10 and
CC       MCP-1 from human macrophages, via the interaction with human Toll-like
CC       receptor 2 (TLR2). {ECO:0000250|UniProtKB:P9WHW9}.
CC   -!- SUBUNIT: Homodimer (By similarity). Interacts with PE35. PE35/PPE68
CC       complex interacts with human TLR2 (By similarity).
CC       {ECO:0000250|UniProtKB:P9WHW9}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC       {ECO:0000250|UniProtKB:P9WHW9}. Cell membrane
CC       {ECO:0000250|UniProtKB:P9WHW9}. Cell surface
CC       {ECO:0000250|UniProtKB:P9WHW9}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK48355.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK48355.1; ALT_INIT; Genomic_DNA.
DR   PIR; G70802; G70802.
DR   RefSeq; WP_003399879.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WHW8; -.
DR   SMR; P9WHW8; -.
DR   EnsemblBacteria; AAK48355; AAK48355; MT3987.
DR   KEGG; mtc:MT3987; -.
DR   PATRIC; fig|83331.31.peg.4289; -.
DR   HOGENOM; CLU_745612_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cell wall; Membrane; Secreted; Virulence.
FT   CHAIN           1..368
FT                   /note="PPE family immunomodulator PPE68"
FT                   /id="PRO_0000428109"
FT   REGION          255..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          312..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        353..368
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   368 AA;  37330 MW;  D78F44095F658CA2 CRC64;
     MLWHAMPPEL NTARLMAGAG PAPMLAAAAG WQTLSAALDA QAVELTARLN SLGEAWTGGG
     SDKALAAATP MVVWLQTAST QAKTRAMQAT AQAAAYTQAM ATTPSLPEIA ANHITQAVLT
     ATNFFGINTI PIALTEMDYF IRMWNQAALA MEVYQAETAV NTLFEKLEPM ASILDPGASQ
     STTNPIFGMP SPGSSTPVGQ LPPAATQTLG QLGEMSGPMQ QLTQPLQQVT SLFSQVGGTG
     GGNPADEEAA QMGLLGTSPL SNHPLAGGSG PSAGAGLLRA ESLPGAGGSL TRTPLMSQLI
     EKPVAPSVMP AAAAGSSATG GAAPVGAGAM GQGAQSGGST RPGLVAPAPL AQEREEDDED
     DWDEEDDW