ID   PPI4_ARATH              Reviewed;         439 AA.
AC   Q8VZN4; Q9LNN6;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Proton pump-interactor 4;
GN   Name=PPI4; OrderedLocusNames=At1g53110; ORFNames=F8L10.22;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12182706; DOI=10.1046/j.1365-313x.2002.01373.x;
RA   Morandini P., Valera M., Albumi C., Bonza M.C., Giacometti S., Ravera G.,
RA   Murgia I., Soave C., De Michelis M.I.;
RT   "A novel interaction partner for the C-terminus of Arabidopsis thaliana
RT   plasma membrane H+-ATPase (AHA1 isoform): site and mechanism of action on
RT   H+-ATPase activity differ from those of 14-3-3 proteins.";
RL   Plant J. 31:487-497(2002).
CC   -!- FUNCTION: May regulate plasma membrane ATPase activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC       protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the plant Proton pump-interactor protein family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF87866.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC022520; AAF87866.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE32892.1; -; Genomic_DNA.
DR   EMBL; AY063988; AAL36344.1; -; mRNA.
DR   PIR; G96571; G96571.
DR   RefSeq; NP_175719.1; NM_104190.4.
DR   AlphaFoldDB; Q8VZN4; -.
DR   SMR; Q8VZN4; -.
DR   STRING; 3702.AT1G53110.1; -.
DR   iPTMnet; Q8VZN4; -.
DR   PaxDb; Q8VZN4; -.
DR   PRIDE; Q8VZN4; -.
DR   ProteomicsDB; 249349; -.
DR   EnsemblPlants; AT1G53110.1; AT1G53110.1; AT1G53110.
DR   GeneID; 841745; -.
DR   Gramene; AT1G53110.1; AT1G53110.1; AT1G53110.
DR   KEGG; ath:AT1G53110; -.
DR   Araport; AT1G53110; -.
DR   TAIR; locus:2037059; AT1G53110.
DR   eggNOG; ENOG502QQX1; Eukaryota.
DR   HOGENOM; CLU_689563_0_0_1; -.
DR   OMA; QSRVVMK; -.
DR   OrthoDB; 1188382at2759; -.
DR   PhylomeDB; Q8VZN4; -.
DR   PRO; PR:Q8VZN4; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q8VZN4; baseline and differential.
DR   Genevisible; Q8VZN4; AT.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0010155; P:regulation of proton transport; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Endoplasmic reticulum; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..439
FT                   /note="Proton pump-interactor 4"
FT                   /id="PRO_0000420216"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          286..354
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   439 AA;  51017 MW;  00CEB03AF9993E0B CRC64;
     MSASILLCDG FDVRRILTGK LNGDESSTVT TEEDDEAVFS GEEWCGESSY CFYFVKQFAY
     DDPEIKAKID EADHEVYHCN TDRIHIANRL KSKRAARLSL VASMETLMSM KINEVEKEQE
     VVRGRIYRLG ERLSEIKMEI ELLDVQMACV LNQRDKAVER IKFLRMQRDK GNAAFYQSRV
     VMKKAIELAA SGNVRDLEEL ADSEVEKFMS RWNNDKAFRD NYKKRILPSV NERKLRCDVQ
     IRDLEGNLDT ENGNETVVKK AIEYKRFSTE EESDDFDIPV YEKLGKEEKE IDEETLKEKK
     REEQLEKARL AMERKRKLHE KAAAKAVIRV KKEAEKKRKE LDKRAKKKKA VCKSSSVDVD
     RTTETVSEAS KPEKEKLLNG RSVFPKQRSY NYRYHGKGND AVLKAIIKRR KAYRLWVWTV
     SSAAVALPLA LLVVFYYVR