ID   PPIA_NAEFO              Reviewed;          21 AA.
AC   P84342;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Peptidyl-prolyl cis-trans isomerase;
DE            Short=PPIase;
DE            EC=5.2.1.8;
DE   AltName: Full=Cyclophilin;
DE   AltName: Full=NF008;
DE   AltName: Full=Rotamase;
DE   Flags: Fragment;
OS   Naegleria fowleri (Brain eating amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5763;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RC   STRAIN=ATCC 30214 / Nf 66;
RA   Omura M., Endo T., Yagita K., Izumiyama S., Furushima-Shimogawara R.;
RL   Submitted (JAN-2005) to UniProtKB.
CC   -!- FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the
CC       cis-trans isomerization of proline imidic peptide bonds in
CC       oligopeptides. {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC         peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC         COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC         ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the cyclophilin-type PPIase family. PPIase A
CC       subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P84342; -.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR   SUPFAM; SSF50891; SSF50891; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Isomerase; Rotamase.
FT   CHAIN           <1..>21
FT                   /note="Peptidyl-prolyl cis-trans isomerase"
FT                   /id="PRO_0000064128"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         21
SQ   SEQUENCE   21 AA;  2300 MW;  06D7FBC81DD639B5 CRC64;
     ENFKIKHTEP GLLSMANAGK N