ID   ATD3C_HUMAN             Reviewed;         411 AA.
AC   Q5T2N8; Q8N1Z5;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=ATPase family AAA domain-containing protein 3C;
GN   Name=ATAD3C;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, and Kidney;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 350-411.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI01212.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC       Sequence=AAI01213.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC       Sequence=BAC04369.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
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DR   EMBL; AK091918; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AK094502; BAC04369.1; ALT_SEQ; mRNA.
DR   EMBL; AL157945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL391244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC101211; AAI01212.1; ALT_SEQ; mRNA.
DR   EMBL; BC101212; AAI01213.1; ALT_SEQ; mRNA.
DR   CCDS; CCDS44039.1; -.
DR   RefSeq; NP_001034300.2; NM_001039211.2.
DR   AlphaFoldDB; Q5T2N8; -.
DR   SMR; Q5T2N8; -.
DR   BioGRID; 128521; 42.
DR   IntAct; Q5T2N8; 9.
DR   MINT; Q5T2N8; -.
DR   STRING; 9606.ENSP00000368062; -.
DR   iPTMnet; Q5T2N8; -.
DR   MetOSite; Q5T2N8; -.
DR   PhosphoSitePlus; Q5T2N8; -.
DR   SwissPalm; Q5T2N8; -.
DR   BioMuta; ATAD3C; -.
DR   DMDM; 162416279; -.
DR   EPD; Q5T2N8; -.
DR   jPOST; Q5T2N8; -.
DR   MassIVE; Q5T2N8; -.
DR   MaxQB; Q5T2N8; -.
DR   PaxDb; Q5T2N8; -.
DR   PeptideAtlas; Q5T2N8; -.
DR   PRIDE; Q5T2N8; -.
DR   ProteomicsDB; 64348; -.
DR   Antibodypedia; 67915; 92 antibodies from 13 providers.
DR   DNASU; 219293; -.
DR   Ensembl; ENST00000378785.7; ENSP00000368062.2; ENSG00000215915.10.
DR   GeneID; 219293; -.
DR   KEGG; hsa:219293; -.
DR   MANE-Select; ENST00000378785.7; ENSP00000368062.2; NM_001039211.3; NP_001034300.2.
DR   UCSC; uc001aft.2; human.
DR   CTD; 219293; -.
DR   GeneCards; ATAD3C; -.
DR   HGNC; HGNC:32151; ATAD3C.
DR   HPA; ENSG00000215915; Tissue enhanced (brain).
DR   neXtProt; NX_Q5T2N8; -.
DR   PharmGKB; PA134903201; -.
DR   VEuPathDB; HostDB:ENSG00000215915; -.
DR   eggNOG; KOG0742; Eukaryota.
DR   GeneTree; ENSGT00940000165354; -.
DR   HOGENOM; CLU_047205_0_0_1; -.
DR   InParanoid; Q5T2N8; -.
DR   OMA; NTKKNHG; -.
DR   OrthoDB; 357201at2759; -.
DR   PhylomeDB; Q5T2N8; -.
DR   TreeFam; TF313922; -.
DR   PathwayCommons; Q5T2N8; -.
DR   SignaLink; Q5T2N8; -.
DR   BioGRID-ORCS; 219293; 8 hits in 1063 CRISPR screens.
DR   ChiTaRS; ATAD3C; human.
DR   GenomeRNAi; 219293; -.
DR   Pharos; Q5T2N8; Tdark.
DR   PRO; PR:Q5T2N8; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q5T2N8; protein.
DR   Bgee; ENSG00000215915; Expressed in body of pancreas and 96 other tissues.
DR   ExpressionAtlas; Q5T2N8; baseline and differential.
DR   Genevisible; Q5T2N8; HS.
DR   GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR039188; ATAD3.
DR   InterPro; IPR021911; ATAD3_N.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR23075; PTHR23075; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF12037; DUF3523; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..411
FT                   /note="ATPase family AAA domain-containing protein 3C"
FT                   /id="PRO_0000311979"
FT   BINDING         177..184
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   411 AA;  46380 MW;  D97236C78380C4C2 CRC64;
     MSKDALNLAQ MQEQTLQLEQ QSKLKQLVNE DLRKQEESVQ KHHQTFLESI RAAGTLFGEG
     FRAFVTDRDK VTATVAGLTL LAVGVYSAKN ATAVTGRYIE ARLGKPSLVR ETSRITVLEA
     LRHPIQQVSR RLLSRPQDVL EGVVLSPSLE ARVRDIAIMT RNIKKNRGLY RHILLYGPPG
     TGKTLFAKKL ALHSGMDYAI MTGGDVAPMG REGVTAMHKL FDWANTSRRG LLLFVDEADA
     FLRKRATEKI SEDLRATLNA FLYRTGQHSN KFMLILASCH PEQFDWAINA CIDVMVHFDL
     PGQEERARLV RMYLNEYVLK PATEGKRRLK LAQFDYGRKC LEIARLTEGM SCRKIAQLAV
     SWQATAYASK DGVLTEAMMD ACVQDFVQQH QQMMRWLKGE RPGPEDEQPS S