AA2BR_BOVIN
ID AA2BR_BOVIN Reviewed; 332 AA.
AC Q1LZD0;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Adenosine receptor A2b;
GN Name=ADORA2B;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Ascending colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for adenosine. The activity of this receptor is
CC mediated by G proteins which activate adenylyl cyclase (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BC116078; AAI16079.1; -; mRNA.
DR RefSeq; NP_001069393.1; NM_001075925.1.
DR AlphaFoldDB; Q1LZD0; -.
DR SMR; Q1LZD0; -.
DR STRING; 9913.ENSBTAP00000009974; -.
DR BindingDB; Q1LZD0; -.
DR PaxDb; Q1LZD0; -.
DR PRIDE; Q1LZD0; -.
DR Ensembl; ENSBTAT00000009974; ENSBTAP00000009974; ENSBTAG00000007581.
DR GeneID; 529760; -.
DR KEGG; bta:529760; -.
DR CTD; 136; -.
DR VEuPathDB; HostDB:ENSBTAG00000007581; -.
DR VGNC; VGNC:25688; ADORA2B.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01030000234555; -.
DR HOGENOM; CLU_009579_11_5_1; -.
DR InParanoid; Q1LZD0; -.
DR OMA; PVKCLFE; -.
DR OrthoDB; 550297at2759; -.
DR TreeFam; TF325296; -.
DR Reactome; R-BTA-417973; Adenosine P1 receptors.
DR Reactome; R-BTA-5683826; Surfactant metabolism.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000007581; Expressed in monocyte and 99 other tissues.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR GO; GO:0001609; F:G protein-coupled adenosine receptor activity; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0031668; P:cellular response to extracellular stimulus; IEA:Ensembl.
DR GO; GO:0019934; P:cGMP-mediated signaling; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0043303; P:mast cell degranulation; IEA:Ensembl.
DR GO; GO:0010753; P:positive regulation of cGMP-mediated signaling; IEA:Ensembl.
DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR GO; GO:0002882; P:positive regulation of chronic inflammatory response to non-antigenic stimulus; IEA:Ensembl.
DR GO; GO:0031284; P:positive regulation of guanylate cyclase activity; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0043306; P:positive regulation of mast cell degranulation; IEA:Ensembl.
DR GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; IEA:Ensembl.
DR GO; GO:0060087; P:relaxation of vascular associated smooth muscle; IEA:Ensembl.
DR GO; GO:0042311; P:vasodilation; IBA:GO_Central.
DR InterPro; IPR001435; Adeno_A2B_rcpt.
DR InterPro; IPR001634; Adenosn_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00554; ADENOSINA2BR.
DR PRINTS; PR00424; ADENOSINER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..332
FT /note="Adenosine receptor A2b"
FT /id="PRO_0000269714"
FT TOPO_DOM 1..8
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 9..33
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 34..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 44..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 68..78
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 79..101
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 102..121
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 122..144
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 145..177
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 178..202
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 203..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 235..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 259..266
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 267..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 291..332
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT BINDING 173
FT /ligand="adenosine"
FT /ligand_id="ChEBI:CHEBI:16335"
FT /ligand_note="agonist"
FT /evidence="ECO:0000250|UniProtKB:P29274"
FT BINDING 253
FT /ligand="adenosine"
FT /ligand_id="ChEBI:CHEBI:16335"
FT /ligand_note="agonist"
FT /evidence="ECO:0000250|UniProtKB:P29274"
FT BINDING 278
FT /ligand="adenosine"
FT /ligand_id="ChEBI:CHEBI:16335"
FT /ligand_note="agonist"
FT /evidence="ECO:0000250|UniProtKB:P29274"
FT BINDING 279
FT /ligand="adenosine"
FT /ligand_id="ChEBI:CHEBI:16335"
FT /ligand_note="agonist"
FT /evidence="ECO:0000250|UniProtKB:P29274"
FT LIPID 310
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 152
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 78..170
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 332 AA; 36385 MW; DCC4B50BFB2E3B29 CRC64;
MPLEAQDAVY VALELALAAL SVTGNVLVCA AVGTSSALQT PTNYFLVSLA AADVAVGLFA
IPFAVTISLG FCTDFHSCLF LACFVLVLTQ SSIFSLLAVA VDRYLAVRVP LRYKSLVTGA
RARGVIAALW VLAFGIGLTP FLGWNDRKIA TNCTEPGDAA TNVSCCLIRC LFENVVPMSY
MVYFNFFGCV LPPLLIMLVI YVKIFLVACR QLQRTELMDH SRTVLQREIH AAKSLALIVG
IFALCWLPVH TINCASLFQP TWAKVKPKWA INTAILLSHA NSAVNPIVYA YRNRDFRYTF
HKIISRYILC RTHILKSGEG QVGSQPTLQL GL
