PPID_CRYNB
ID PPID_CRYNB Reviewed; 375 AA.
AC P0CP81; Q55QB1; Q5KFV5;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=Peptidyl-prolyl cis-trans isomerase D;
DE Short=PPIase D;
DE EC=5.2.1.8;
DE AltName: Full=Rotamase D;
GN Name=CPR6; OrderedLocusNames=CNBF4260;
OS Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=283643;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-3501A;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the
CC cis-trans isomerization of proline imidic peptide bonds in
CC oligopeptides (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cyclophilin-type PPIase family. PPIase D
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAEY01000032; EAL20100.1; -; Genomic_DNA.
DR RefSeq; XP_774747.1; XM_769654.1.
DR AlphaFoldDB; P0CP81; -.
DR SMR; P0CP81; -.
DR EnsemblFungi; EAL20100; EAL20100; CNBF4260.
DR GeneID; 4936978; -.
DR KEGG; cnb:CNBF4260; -.
DR VEuPathDB; FungiDB:CNBF4260; -.
DR HOGENOM; CLU_012062_37_0_1; -.
DR Proteomes; UP000001435; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:InterPro.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 2.40.100.10; -; 1.
DR InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF00160; Pro_isomerase; 1.
DR PRINTS; PR00153; CSAPPISMRASE.
DR SUPFAM; SSF48452; SSF48452; 1.
DR SUPFAM; SSF50891; SSF50891; 1.
DR PROSITE; PS50072; CSA_PPIASE_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Isomerase; Repeat; Rotamase; TPR repeat.
FT CHAIN 1..375
FT /note="Peptidyl-prolyl cis-trans isomerase D"
FT /id="PRO_0000410200"
FT DOMAIN 7..169
FT /note="PPIase cyclophilin-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00156"
FT REPEAT 217..250
FT /note="TPR 1"
FT REPEAT 270..307
FT /note="TPR 2"
FT REPEAT 312..345
FT /note="TPR 3"
SQ SEQUENCE 375 AA; 40995 MW; 2756FC18EC2156CE CRC64;
MSNTIAYFDI TIANEPAGRL TFELFDDVVP KTANNFKHLC IGDKTNEAGV KLAYAGSSFH
RCIKGFMLQG GDFTRGDGTG GESIYGEKFE DENFELKHDK PMLLSMANAG PGTNGSQFFI
TTVPTPHLDG KHVVFGRVIY NRSLVRRIEN IPTTSDRPDQ EVTISSAGVL SPDEFAQLEA
ERQAKQAGSD GGDIWEDWPQ DEEGVDAEKP EEALVVAGKL KEVGTKEFKA GNFAVALDKY
QKALRYLDVH PVLPNDSPAE LVESFRSLRL PLLTNAALCA LKLPASPNTS SLVVSLTSRA
LTLPNLSASE KGKALYRRAQ AYVLKKDDEA AEKDLKGALE CVPGDAGVIK LLKDVEAKRK
ARREKERQAF AKMFG