ID   PPIE_SCHJA              Reviewed;         179 AA.
AC   Q26516;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Peptidyl-prolyl cis-trans isomerase E;
DE            Short=PPIase E;
DE            EC=5.2.1.8;
DE   AltName: Full=Cyclophilin E;
DE   AltName: Full=Rotamase E;
DE   Flags: Fragment;
OS   Schistosoma japonicum (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6182;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Philippines;
RX   PubMed=1635025; DOI=10.2307/3283541;
RA   Argaet V.P., Mitchell G.F.;
RT   "Cyclophilin of Schistosoma japonicum.";
RL   J. Parasitol. 78:660-664(1992).
CC   -!- FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the
CC       cis-trans isomerization of proline imidic peptide bonds in
CC       oligopeptides.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC         peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC         COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC         ChEBI:CHEBI:83834; EC=5.2.1.8;
CC   -!- ACTIVITY REGULATION: Binds cyclosporin A (CsA). CsA mediates some of
CC       its effects via an inhibitory action on PPIase.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the cyclophilin-type PPIase family. PPIase E
CC       subfamily. {ECO:0000305}.
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DR   EMBL; M93420; AAA29863.1; -; mRNA.
DR   AlphaFoldDB; Q26516; -.
DR   SMR; Q26516; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   GO; GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:InterPro.
DR   Gene3D; 2.40.100.10; -; 1.
DR   InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR   InterPro; IPR024936; Cyclophilin-type_PPIase.
DR   InterPro; IPR020892; Cyclophilin-type_PPIase_CS.
DR   InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR   Pfam; PF00160; Pro_isomerase; 1.
DR   PIRSF; PIRSF001467; Peptidylpro_ismrse; 1.
DR   PRINTS; PR00153; CSAPPISMRASE.
DR   SUPFAM; SSF50891; SSF50891; 1.
DR   PROSITE; PS00170; CSA_PPIASE_1; 1.
DR   PROSITE; PS50072; CSA_PPIASE_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Isomerase; Rotamase.
FT   CHAIN           <1..179
FT                   /note="Peptidyl-prolyl cis-trans isomerase E"
FT                   /id="PRO_0000064160"
FT   DOMAIN          21..177
FT                   /note="PPIase cyclophilin-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00156"
FT   NON_TER         1
SQ   SEQUENCE   179 AA;  20050 MW;  4ADA71B386175DAC CRC64;
     EDVSDDEMRT KKQKRNLPRV FFDIRIGNAD RGRIVMELRS DIVPRTAENF RALCTGDRGF
     GYHNCCFHRV IPQFMCQGGD FVKGDGTGGK SIYGRKFDDE NFQLRHEGFG VLSMANSGPN
     TNGSQFFICT TKCDWLDGKH VVFGRVVDGQ NVVKKMESVG SKSGKVKEPV TISRCGELI