PPIP2_HUMAN
ID PPIP2_HUMAN Reviewed; 334 AA.
AC Q9H939;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 4.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Proline-serine-threonine phosphatase-interacting protein 2;
DE Short=PEST phosphatase-interacting protein 2;
GN Name=PSTPIP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 113-334 (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Binds to F-actin. May be involved in regulation of the actin
CC cytoskeleton (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H939-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H939-2; Sequence=VSP_004070;
CC -!- PTM: Phosphorylated on tyrosine. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14404.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC012569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC035395; AAH35395.1; -; mRNA.
DR EMBL; AK023100; BAB14404.1; ALT_INIT; mRNA.
DR CCDS; CCDS32820.2; -. [Q9H939-1]
DR RefSeq; NP_077748.3; NM_024430.3. [Q9H939-1]
DR AlphaFoldDB; Q9H939; -.
DR SMR; Q9H939; -.
DR BioGRID; 114512; 17.
DR IntAct; Q9H939; 12.
DR MINT; Q9H939; -.
DR STRING; 9606.ENSP00000387261; -.
DR iPTMnet; Q9H939; -.
DR PhosphoSitePlus; Q9H939; -.
DR BioMuta; PSTPIP2; -.
DR DMDM; 294862539; -.
DR EPD; Q9H939; -.
DR jPOST; Q9H939; -.
DR MassIVE; Q9H939; -.
DR MaxQB; Q9H939; -.
DR PaxDb; Q9H939; -.
DR PeptideAtlas; Q9H939; -.
DR PRIDE; Q9H939; -.
DR ProteomicsDB; 81278; -. [Q9H939-1]
DR ProteomicsDB; 81279; -. [Q9H939-2]
DR Antibodypedia; 22437; 94 antibodies from 20 providers.
DR DNASU; 9050; -.
DR Ensembl; ENST00000409746.5; ENSP00000387261.4; ENSG00000152229.18. [Q9H939-1]
DR Ensembl; ENST00000589328.5; ENSP00000468622.1; ENSG00000152229.18. [Q9H939-2]
DR GeneID; 9050; -.
DR KEGG; hsa:9050; -.
DR MANE-Select; ENST00000409746.5; ENSP00000387261.4; NM_024430.4; NP_077748.3.
DR UCSC; uc002lbp.5; human. [Q9H939-1]
DR CTD; 9050; -.
DR DisGeNET; 9050; -.
DR GeneCards; PSTPIP2; -.
DR HGNC; HGNC:9581; PSTPIP2.
DR HPA; ENSG00000152229; Group enriched (bone marrow, lymphoid tissue, skeletal muscle).
DR MIM; 616046; gene.
DR neXtProt; NX_Q9H939; -.
DR OpenTargets; ENSG00000152229; -.
DR PharmGKB; PA33932; -.
DR VEuPathDB; HostDB:ENSG00000152229; -.
DR eggNOG; KOG2398; Eukaryota.
DR GeneTree; ENSGT00940000158788; -.
DR HOGENOM; CLU_038196_1_1_1; -.
DR InParanoid; Q9H939; -.
DR OMA; EEADQNM; -.
DR PhylomeDB; Q9H939; -.
DR TreeFam; TF313677; -.
DR PathwayCommons; Q9H939; -.
DR SignaLink; Q9H939; -.
DR BioGRID-ORCS; 9050; 6 hits in 1081 CRISPR screens.
DR ChiTaRS; PSTPIP2; human.
DR GeneWiki; PSTPIP2; -.
DR GenomeRNAi; 9050; -.
DR Pharos; Q9H939; Tbio.
DR PRO; PR:Q9H939; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q9H939; protein.
DR Bgee; ENSG00000152229; Expressed in spleen and 125 other tissues.
DR ExpressionAtlas; Q9H939; baseline and differential.
DR Genevisible; Q9H939; HS.
DR GO; GO:0005884; C:actin filament; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0030041; P:actin filament polymerization; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IEA:InterPro.
DR CDD; cd07672; F-BAR_PSTPIP2; 1.
DR Gene3D; 1.20.1270.60; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR030106; PSTPIP2.
DR InterPro; IPR042694; PSTPIP2_F-BAR.
DR PANTHER; PTHR23065:SF9; PTHR23065:SF9; 1.
DR Pfam; PF00611; FCH; 1.
DR SMART; SM00055; FCH; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR PROSITE; PS51741; F_BAR; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Membrane; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..334
FT /note="Proline-serine-threonine phosphatase-interacting
FT protein 2"
FT /id="PRO_0000058541"
FT DOMAIN 4..264
FT /note="F-BAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01077"
FT REGION 295..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 66..166
FT /evidence="ECO:0000255"
FT MOD_RES 323
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q99M15"
FT MOD_RES 329
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q99M15"
FT VAR_SEQ 248..334
FT /note="MYEQVRKSLEMCSIQRDIEYFVNQRKTGQIPPAPIMYENFYSSQKNAVPAGK
FT ATGPNLARRGPLPIPKSSPDDPNYSLVDDYSLLYQ -> HPSCMRISTPPRRMQSQQER
FT LQGLTWQGEDPSQFLKAHQMIPITLWLMTTVCSISKINETRAFSG (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_004070"
FT VARIANT 322
FT /note="N -> D (in dbSNP:rs2276199)"
FT /id="VAR_059708"
FT VARIANT 322
FT /note="N -> S (in dbSNP:rs16978507)"
FT /id="VAR_059709"
FT CONFLICT 284
FT /note="Y -> H (in Ref. 3; BAB14404)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 334 AA; 38858 MW; DD7DC17EC3F6E165 CRC64;
MTRSLFKGNF WSADILSTIG YDNIIQHLNN GRKNCKEFED FLKERAAIEE RYGKDLLNLS
RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQSLRE EARKMEEFRE KQKLQRKKTE
LIMDAIHKQK SLQFKKTMDA KKNYEQKCRD KDEAEQAVSR SANLVNPKQQ EKLFVKLATS
KTAVEDSDKA YMLHIGTLDK VREEWQSEHI KACEAFEAQE CERINFFRNA LWLHVNQLSQ
QCVTSDEMYE QVRKSLEMCS IQRDIEYFVN QRKTGQIPPA PIMYENFYSS QKNAVPAGKA
TGPNLARRGP LPIPKSSPDD PNYSLVDDYS LLYQ
