ATF1_BOVIN
ID ATF1_BOVIN Reviewed; 270 AA.
AC Q08DA8;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Cyclic AMP-dependent transcription factor ATF-1;
DE Short=cAMP-dependent transcription factor ATF-1;
DE AltName: Full=Activating transcription factor 1;
GN Name=ATF1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Brain cortex;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein binds the cAMP response element (CRE)
CC (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral
CC and cellular promoters. Mediates PKA-induced stimulation of CRE-
CC reporter genes. Represses the expression of FTH1 and other antioxidant
CC detoxification genes. Triggers cell proliferation and transformation
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds DNA as a dimer. Interacts with HIPK2 and CDK3. Interacts
CC with MOTS-c, a peptide produced by the mitochondrially encoded 12S rRNA
CC MT-RNR1; the interaction occurs in the nucleus following metabolic
CC stress. {ECO:0000250|UniProtKB:P18846}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00312,
CC ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- PTM: Phosphorylated at Ser-197 by HIPK2 in response to genotoxic
CC stress. This phosphorylation promotes transcription repression of FTH1
CC and other antioxidant detoxification genes. The CDK3-mediated
CC phosphorylation at Ser-63 promotes its transactivation and
CC transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and
CC RPS6KA5 in response to mitogenic or stress stimuli (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the bZIP family. ATF subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC123855; AAI23856.1; -; mRNA.
DR RefSeq; NP_001068757.1; NM_001075289.1.
DR RefSeq; XP_005206335.1; XM_005206278.3.
DR AlphaFoldDB; Q08DA8; -.
DR STRING; 9913.ENSBTAP00000024135; -.
DR iPTMnet; Q08DA8; -.
DR PaxDb; Q08DA8; -.
DR PRIDE; Q08DA8; -.
DR Ensembl; ENSBTAT00000024135; ENSBTAP00000024135; ENSBTAG00000018131.
DR GeneID; 506967; -.
DR KEGG; bta:506967; -.
DR CTD; 466; -.
DR VEuPathDB; HostDB:ENSBTAG00000018131; -.
DR VGNC; VGNC:26239; ATF1.
DR eggNOG; KOG3584; Eukaryota.
DR GeneTree; ENSGT00940000158200; -.
DR HOGENOM; CLU_042675_1_0_1; -.
DR InParanoid; Q08DA8; -.
DR OrthoDB; 957343at2759; -.
DR TreeFam; TF106464; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000018131; Expressed in milk and 105 other tissues.
DR ExpressionAtlas; Q08DA8; baseline and differential.
DR GO; GO:1990589; C:ATF4-CREB1 transcription factor complex; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR029825; ATF1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR003102; Coactivator_CBP_pKID.
DR InterPro; IPR001630; Leuzip_CREB.
DR PANTHER; PTHR45879; PTHR45879; 1.
DR PANTHER; PTHR45879:SF2; PTHR45879:SF2; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR Pfam; PF02173; pKID; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
DR PROSITE; PS50953; KID; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation;
KW Ubl conjugation.
FT CHAIN 1..270
FT /note="Cyclic AMP-dependent transcription factor ATF-1"
FT /id="PRO_0000285214"
FT DOMAIN 31..90
FT /note="KID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00312"
FT DOMAIN 212..270
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..238
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 240..261
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT COMPBIAS 8..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 63
FT /note="Phosphoserine; by CaMK1, CDK3, RPS6KA4 and RPS6KA5"
FT /evidence="ECO:0000250|UniProtKB:P18846,
FT ECO:0000255|PROSITE-ProRule:PRU00312"
FT MOD_RES 197
FT /note="Phosphoserine; by HIPK2"
FT /evidence="ECO:0000250|UniProtKB:P18846,
FT ECO:0000255|PROSITE-ProRule:PRU00312"
FT CROSSLNK 207
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P18846"
FT CROSSLNK 214
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P18846"
SQ SEQUENCE 270 AA; 29261 MW; 4DC5B06A6CBC7103 CRC64;
MEDSHKSNTS ETAPQSGSTV QAAHISHIAQ QVSSLSESEE SQDSSDSIGS SQKTHGILAR
RPSYRKILKD LSSEDIRGRK GDGENPGVSA VTSMSVPTPI YQTSTGQYIA IAPNGALQLA
SPGTDGVQGL QTLTMTNSGS TQQGTTILQY AQTSDGQQIL VPSNQVVVQT ASGDMQTYQI
RTTPSATSLP QTVVMTSPVT LTSQTSKTDD PQLKREIRLM KNREAARECR RKKKEYVKCL
ENRVAVLENQ NKTLIEELKT LKDLYSNKSV
