ATF21_SCHPO
ID ATF21_SCHPO Reviewed; 355 AA.
AC P78962;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 25-MAY-2022, entry version 138.
DE RecName: Full=Transcription factor atf21;
GN Name=atf21; ORFNames=SPBC2F12.09c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=8824587; DOI=10.1101/gad.10.18.2276;
RA Shiozaki K., Russell P.;
RT "Conjugation, meiosis, and the osmotic stress response are regulated by
RT Spc1 kinase through Atf1 transcription factor in fission yeast.";
RL Genes Dev. 10:2276-2288(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; U51566; AAB40604.1; -; Genomic_DNA.
DR EMBL; CU329671; CAB10164.1; -; Genomic_DNA.
DR PIR; T40132; T40132.
DR RefSeq; NP_595707.1; NM_001021604.2.
DR AlphaFoldDB; P78962; -.
DR SMR; P78962; -.
DR BioGRID; 276892; 29.
DR STRING; 4896.SPBC2F12.09c.1; -.
DR PaxDb; P78962; -.
DR PRIDE; P78962; -.
DR EnsemblFungi; SPBC2F12.09c.1; SPBC2F12.09c.1:pep; SPBC2F12.09c.
DR GeneID; 2540363; -.
DR KEGG; spo:SPBC2F12.09c; -.
DR PomBase; SPBC2F12.09c; atf21.
DR VEuPathDB; FungiDB:SPBC2F12.09c; -.
DR eggNOG; KOG1414; Eukaryota.
DR HOGENOM; CLU_806887_0_0_1; -.
DR InParanoid; P78962; -.
DR PhylomeDB; P78962; -.
DR Reactome; R-SPO-3214847; HATs acetylate histones.
DR Reactome; R-SPO-450341; Activation of the AP-1 family of transcription factors.
DR PRO; PR:P78962; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISM:PomBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISM:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010672; P:regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle; IMP:PomBase.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR002112; Leuzip_Jun.
DR Pfam; PF00170; bZIP_1; 1.
DR PRINTS; PR00043; LEUZIPPRJUN.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 3: Inferred from homology;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..355
FT /note="Transcription factor atf21"
FT /id="PRO_0000076534"
FT DOMAIN 267..330
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 218..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..307
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 309..323
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT COMPBIAS 218..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 355 AA; 39417 MW; 54A86CAD96B3CB12 CRC64;
MDFANVYLGL DTLGNEGYGA SVSNGTHHDF HFNFNTFRDG GNHEVGEKRA ESSDIGVYEC
RGPVQGPKDQ TSFPSNSHNN YASIVGDASI GHYLKGPERT SEVSLPQTVN LSEISNNNDK
GQPTNTPPVR STIVAPSLYS EGSTLNHYNN GSHQVLHPQF QNGTNAPYVV QSNLMQNNVN
LTGAEQEKGL DLYKNSATAN NDEIFYNLES LRREGYLNSN KKQSQSPNGD YNSSDESCSN
KTVASSQRRG TPGSNNVHTA SNNETPDMKR RRFLERNRIA ASKCRQKKKL WTQNLEKTAH
IACEQSKALR ILVSQLREEV ICLKNQLLAH QDCNCEGIRQ YLSSEAQGIM SFQKH
