ID   PPK2_PERAM              Reviewed;           8 AA.
AC   P82692;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   11-DEC-2019, entry version 53.
DE   RecName: Full=Pyrokinin-2;
DE            Short=Pea-PK-2;
DE   AltName: Full=FXPRL-amide;
OS   Periplaneta americana (American cockroach) (Blatta americana).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC   Blattinae; Periplaneta.
OX   NCBI_TaxID=6978;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT LEU-8, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=9210163; DOI=10.1016/s0196-9781(97)00067-3;
RA   Predel R., Kellner R., Kaufmann R., Penzlin H., Gaede G.;
RT   "Isolation and structural elucidation of two pyrokinins from the
RT   retrocerebral complex of the American cockroach.";
RL   Peptides 18:473-478(1997).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=10723010;
RX   DOI=10.1002/(sici)1096-9861(20000410)419:3<352::aid-cne7>3.0.co;2-0;
RA   Predel R., Eckert M.;
RT   "Tagma-specific distribution of FXPRLamides in the nervous system of the
RT   American cockroach.";
RL   J. Comp. Neurol. 419:352-363(2000).
CC   -!- FUNCTION: Mediates visceral muscle contractile activity (myotropic
CC       activity). {ECO:0000269|PubMed:9210163}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Corpora cardiaca. {ECO:0000269|PubMed:10723010}.
CC   -!- MASS SPECTROMETRY: Mass=883; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:9210163};
CC   -!- SIMILARITY: Belongs to the pyrokinin family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..8
FT                   /note="Pyrokinin-2"
FT                   /id="PRO_0000044323"
FT   MOD_RES         8
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:9210163"
SQ   SEQUENCE   8 AA;  884 MW;  C834176DD9D77775 CRC64;
     SPPFAPRL