PPK3_SCHPO
ID PPK3_SCHPO Reviewed; 637 AA.
AC O13733;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein kinase domain-containing protein ppk3;
GN Name=ppk3; ORFNames=SPAC15A10.13;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP IDENTIFICATION.
RX PubMed=15821139; DOI=10.1128/ec.4.4.799-813.2005;
RA Bimbo A., Jia Y., Poh S.L., Karuturi R.K.M., den Elzen N., Peng X.,
RA Zheng L., O'Connell M., Liu E.T., Balasubramanian M.K., Liu J.;
RT "Systematic deletion analysis of fission yeast protein kinases.";
RL Eukaryot. Cell 4:799-813(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:16823372}.
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
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DR EMBL; CU329670; CAB10110.1; -; Genomic_DNA.
DR PIR; T37713; T37713.
DR RefSeq; NP_594300.1; NM_001019723.2.
DR AlphaFoldDB; O13733; -.
DR SMR; O13733; -.
DR BioGRID; 279191; 1.
DR STRING; 4896.SPAC15A10.13.1; -.
DR iPTMnet; O13733; -.
DR MaxQB; O13733; -.
DR PaxDb; O13733; -.
DR PRIDE; O13733; -.
DR EnsemblFungi; SPAC15A10.13.1; SPAC15A10.13.1:pep; SPAC15A10.13.
DR GeneID; 2542741; -.
DR KEGG; spo:SPAC15A10.13; -.
DR PomBase; SPAC15A10.13; ppk3.
DR VEuPathDB; FungiDB:SPAC15A10.13; -.
DR eggNOG; KOG1243; Eukaryota.
DR HOGENOM; CLU_010392_1_0_1; -.
DR InParanoid; O13733; -.
DR OMA; LIRDQAN; -.
DR PhylomeDB; O13733; -.
DR PRO; PR:O13733; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR GO; GO:0006409; P:tRNA export from nucleus; ISO:PomBase.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Golgi apparatus; Reference proteome.
FT CHAIN 1..637
FT /note="Protein kinase domain-containing protein ppk3"
FT /id="PRO_0000116647"
FT DOMAIN 1..296
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REPEAT 414..450
FT /note="HEAT"
FT REGION 576..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..631
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 637 AA; 71633 MW; CF6BC31F51A1D2A0 CRC64;
MDFIKSAASF IAKAGSQFPY DLNEKIPLSS NSVWTLQTGS IRESAQPCSV FSISLSTHPE
WAELADRACE TMKTLRHPCI IKYLSTYKSS THLYIATETV RPVTTELNEL SAEIKTYGLW
RVSAALSFLN DKNIVHGNLQ MSSVYLNSAD EWIIGDFFLA GDSPQFIKDN HDKILNWSRL
VPFEIQSSTL NSASFIYLDS YELGKFISHL YNGTPGDLSQ RGNIPANIFV SAKKLLNVEG
KQKLLASEFL KLGERPGGFF RTHLITLYEL LSEVRINEEE DRVKLKQLLS SKLEVIPKNY
IQKVVLNILF LLLSIDTHSD VVELLFKCAQ IVKGRPDIEK DFGVPLLSLL KQQSVPIRGL
LLSGIINNPD VLPKNIYEDT SFSVFANLVR SNSPTLKEHA IVVFSIIAPK LSKKTLNNEL
LRSLAVVQND QHPTLRTNST ICLGKIAEYL DASVRKPVLA AALSRSLKDP FVPAREAALK
VLLSVQNYFD TKDVAIKLFP SVVPLLIDEN EGIRRTAEDV TDQFLSRIKN FNLGEKENVS
APAKFNGSFW SKFIHSSSAS PSPSIDMKKE SLELKNDTTE IKEKKNSKSR VVGNTENSKD
EFNNPLFETE EQIDESWMEN WNDEEETENN VEESWGL
