ID   PPK4_PERAM              Reviewed;          12 AA.
AC   P82619;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   11-DEC-2019, entry version 51.
DE   RecName: Full=Pyrokinin-4;
DE            Short=Pea-PK-4;
DE   AltName: Full=YXPRL-amide;
OS   Periplaneta americana (American cockroach) (Blatta americana).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC   Blattinae; Periplaneta.
OX   NCBI_TaxID=6978;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT LEU-12, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Retrocerebral complex;
RX   PubMed=10196736; DOI=10.1016/s0965-1748(98)00117-9;
RA   Predel R., Kellner R., Nachman R.J., Holman G.M., Rapus J., Gaede G.;
RT   "Differential distribution of pyrokinin-isoforms in cerebral and abdominal
RT   neurohemal organs of the American cockroach.";
RL   Insect Biochem. Mol. Biol. 29:139-144(1999).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=10723010;
RX   DOI=10.1002/(sici)1096-9861(20000410)419:3<352::aid-cne7>3.0.co;2-0;
RA   Predel R., Eckert M.;
RT   "Tagma-specific distribution of FXPRLamides in the nervous system of the
RT   American cockroach.";
RL   J. Comp. Neurol. 419:352-363(2000).
CC   -!- FUNCTION: Mediates visceral muscle contractile activity (myotropic
CC       activity). {ECO:0000269|PubMed:10196736}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Corpora cardiaca. {ECO:0000269|PubMed:10723010}.
CC   -!- MASS SPECTROMETRY: Mass=1147.9; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:10196736};
CC   -!- SIMILARITY: Belongs to the pyrokinin family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..12
FT                   /note="Pyrokinin-4"
FT                   /id="PRO_0000044332"
FT   MOD_RES         12
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:10196736"
SQ   SEQUENCE   12 AA;  1449 MW;  FA7A3049FF42CAA1 CRC64;
     DHLPHDVYSP RL