PPK4_PERFU
ID PPK4_PERFU Reviewed; 12 AA.
AC P82690;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 11-DEC-2019, entry version 53.
DE RecName: Full=Pyrokinin-4;
DE Short=Pef-PK-4;
DE AltName: Full=YXPRL-amide;
OS Periplaneta fuliginosa (Smokybrown cockroach) (Dusky-brown cockroach).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC Blattinae; Periplaneta.
OX NCBI_TaxID=36977;
RN [1]
RP PROTEIN SEQUENCE, AMIDATION, FUNCTION, AND MASS SPECTROMETRY.
RC TISSUE=Corpora cardiaca;
RX PubMed=10723010;
RX DOI=10.1002/(sici)1096-9861(20000410)419:3<352::aid-cne7>3.0.co;2-0;
RA Predel R., Eckert M.;
RT "Tagma-specific distribution of FXPRLamides in the nervous system of the
RT American cockroach.";
RL J. Comp. Neurol. 419:352-363(2000).
RN [2]
RP PROTEIN SEQUENCE, AMIDATION AT LEU-12, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Corpora allata;
RX PubMed=15626499; DOI=10.1016/j.peptides.2004.10.010;
RA Predel R., Gaede G.;
RT "Peptidomics of neurohemal organs from species of the cockroach family
RT Blattidae: how do neuropeptides of closely related species differ?";
RL Peptides 26:3-9(2005).
RN [3]
RP TISSUE SPECIFICITY.
RA Predel R., Gaede G.;
RL Submitted (NOV-2004) to UniProtKB.
CC -!- FUNCTION: Mediates visceral muscle contractile activity (myotropic
CC activity). {ECO:0000269|PubMed:10723010}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in the brain, subesophageal ganglion and
CC in the retrocerebral complex (mainly corpora allata).
CC {ECO:0000269|Ref.3}.
CC -!- MASS SPECTROMETRY: Mass=1437.9; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:10723010};
CC -!- SIMILARITY: Belongs to the pyrokinin family. {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT PEPTIDE 1..12
FT /note="Pyrokinin-4"
FT /id="PRO_0000044335"
FT MOD_RES 12
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:15626499"
SQ SEQUENCE 12 AA; 1439 MW; F9B53049FF42CAA1 CRC64;
DHLSHDVYSP RL