ATF4H_CAEEL
ID ATF4H_CAEEL Reviewed; 208 AA.
AC Q22156;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Transcription factor atf-4 homolog {ECO:0000303|PubMed:35181679};
DE AltName: Full=cAMP-dependent transcription factor family member 4 {ECO:0000312|WormBase:T04C10.4};
GN Name=atf-4 {ECO:0000312|WormBase:T04C10.4};
GN Synonyms=atf-5 {ECO:0000312|WormBase:T04C10.4};
GN ORFNames=T04C10.4 {ECO:0000312|WormBase:T04C10.4};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, INDUCTION, DEVELOPMENTAL STAGE, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=35181679; DOI=10.1038/s41467-022-28599-9;
RA Statzer C., Meng J., Venz R., Bland M., Robida-Stubbs S., Patel K.,
RA Petrovic D., Emsley R., Liu P., Morantte I., Haynes C., Mair W.B.,
RA Longchamp A., Filipovic M.R., Blackwell T.K., Ewald C.Y.;
RT "ATF-4 and hydrogen sulfide signalling mediate longevity in response to
RT inhibition of translation or mTORC1.";
RL Nat. Commun. 13:967-967(2022).
CC -!- FUNCTION: Transcription factor (By similarity). Involved in positively
CC modulating longevity and stress tolerance, probably acting by
CC positively regulating expression of transsulfuration enzyme cth-2,
CC leading to increased hydrogen sulfide production and therefore
CC increased protein persulfidation, a protective modification of redox-
CC reactive cysteines (PubMed:35181679). May mediate longevity and
CC increased stress resistance induced by mTORC1 suppression
CC (PubMed:35181679). {ECO:0000250|UniProtKB:P18848,
CC ECO:0000269|PubMed:35181679}.
CC -!- INTERACTION:
CC Q22156; Q8IG69: cebp-2; NbExp=3; IntAct=EBI-6749607, EBI-2914231;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978,
CC ECO:0000305|PubMed:35181679}.
CC -!- DEVELOPMENTAL STAGE: Expressed at steady levels during development and
CC aging. {ECO:0000269|PubMed:35181679}.
CC -!- INDUCTION: Positively modulated by global suppression of translation
CC activated via integrated stress response.
CC {ECO:0000269|PubMed:35181679}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown abrogates an increase in
CC hydrogen-sulfide production in an mTORC2 subunit rict-1 mutant
CC background. {ECO:0000269|PubMed:35181679}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; BX284606; CAA93757.1; -; Genomic_DNA.
DR PIR; T24446; T24446.
DR RefSeq; NP_510456.1; NM_078055.4.
DR SMR; Q22156; -.
DR IntAct; Q22156; 8.
DR STRING; 6239.T04C10.4.2; -.
DR PaxDb; Q22156; -.
DR EnsemblMetazoa; T04C10.4.1; T04C10.4.1; WBGene00000221.
DR EnsemblMetazoa; T04C10.4.2; T04C10.4.2; WBGene00000221.
DR GeneID; 181576; -.
DR KEGG; cel:CELE_T04C10.4; -.
DR UCSC; T04C10.4; c. elegans.
DR CTD; 181576; -.
DR WormBase; T04C10.4; CE06355; WBGene00000221; atf-4.
DR eggNOG; KOG4571; Eukaryota.
DR GeneTree; ENSGT00530000063801; -.
DR HOGENOM; CLU_1190780_0_0_1; -.
DR InParanoid; Q22156; -.
DR OrthoDB; 1117408at2759; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00000221; Expressed in larva and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR Pfam; PF00170; bZIP_1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..208
FT /note="Transcription factor atf-4 homolog"
FT /id="PRO_0000455978"
FT DOMAIN 138..201
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 140..163
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 173..187
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
SQ SEQUENCE 208 AA; 24573 MW; D2849040E481E59D CRC64;
MAYVNEQNPQ FLLYNGMHNQ THSTPQYHNH HHHHHQSPTY PQSYFNPYSH QSYQQHHLNS
DVNFQMVPQS TSVPPDPFCS IEPMETNVQA KEQILEEIVR ECEEIERRSN SSASPASNWS
SDEHDSQSEK SYHPYKTPEK KERKKAQNRL AATRYREKKR REKEEAMTCI EGLSVTNGKL
KDQVSELERE IRYFKKFMTE MGMKTVTD
