ID   PPM1H_XENTR             Reviewed;         510 AA.
AC   Q28DF4;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Protein phosphatase 1H;
DE            EC=3.1.3.16;
GN   Name=ppm1h; ORFNames=TEgg016i20.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:83421; EC=3.1.3.16;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC         COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:61977; EC=3.1.3.16;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9ULR3}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9ULR3}.
CC   -!- SIMILARITY: Belongs to the PP2C family. {ECO:0000305}.
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DR   EMBL; CR855546; CAJ82033.1; -; mRNA.
DR   RefSeq; NP_001017305.1; NM_001017305.2.
DR   AlphaFoldDB; Q28DF4; -.
DR   SMR; Q28DF4; -.
DR   STRING; 8364.ENSXETP00000040719; -.
DR   GeneID; 550059; -.
DR   KEGG; xtr:550059; -.
DR   CTD; 57460; -.
DR   Xenbase; XB-GENE-5872503; ppm1h.
DR   eggNOG; KOG1323; Eukaryota.
DR   InParanoid; Q28DF4; -.
DR   OrthoDB; 601888at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000018793; Expressed in early embryo and 12 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; ISS:UniProtKB.
DR   GO; GO:0006470; P:protein dephosphorylation; IBA:GO_Central.
DR   CDD; cd00143; PP2Cc; 1.
DR   Gene3D; 3.60.40.10; -; 1.
DR   InterPro; IPR015655; PP2C.
DR   InterPro; IPR036457; PPM-type_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase_dom.
DR   PANTHER; PTHR13832; PTHR13832; 1.
DR   Pfam; PF00481; PP2C; 2.
DR   SMART; SM00332; PP2Cc; 1.
DR   SUPFAM; SSF81606; SSF81606; 1.
DR   PROSITE; PS51746; PPM_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Hydrolase; Nucleus; Protein phosphatase; Reference proteome.
FT   CHAIN           1..510
FT                   /note="Protein phosphatase 1H"
FT                   /id="PRO_0000286607"
FT   DOMAIN          73..503
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01082"
FT   REGION          105..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..127
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        190..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   510 AA;  56461 MW;  1FA4AB5EF752A5A0 CRC64;
     MFTRVKSAVV SFMGGIMAGS SGLEHVNGSD LPVRFSYTRP EFLGLSPDEI ECSADHIARP
     ILILKETQRL PWSTGYAEVI NAGKSTHNED QASCEVVFVK KKSGVQSTPN KNSSSKRRSS
     LPNAEGLQLK DNQEVDGITF HYWALFDGHA GAGAAVVASK LLHHHIAEQI PDIIDILKNS
     AVLPPTCLGE EPESTSSNSR TLTRAASLRG GSGAPGSPST PPTRFFTEKK IPHECLVIGA
     LENAFKEMDL RIERERSTYS ISGGCTALIV VYLLGKLYVA NAGDSRAIII RNGEIIPMSS
     EFTPETERQR LQYLAFLQPH LLGNEFTHLE FPRRVQRKEV GKMMLYRDFN MTGWAYKTIE
     ENDLKFPLIY GEGKKARVMA TIGVTRGLGD HDLKVHDSNI YIKPFLSSVP EVRVYDLVQH
     EHSADDVLVL ATDGLWDVLF NEEVLEAVTS FLANCDPDDP HRYTLAAQDL VMRARGVLKD
     RGWRISNDRL GSGDDISVYV IPLEHGNRVS